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PubMed:8955094 JSONTXT 31 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
T1 0-113 Sentence denotes Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
T2 114-289 Sentence denotes The protein-tyrosine kinase ZAP-70 is implicated, together with the Src kinase p56(lck), in controlling the early steps of the T-cell antigen receptor (TCR) signaling cascade.
T2 114-289 Sentence denotes The protein-tyrosine kinase ZAP-70 is implicated, together with the Src kinase p56(lck), in controlling the early steps of the T-cell antigen receptor (TCR) signaling cascade.
T3 290-422 Sentence denotes To help elucidate further the mechanism by which ZAP-70 regulates these initial events, we used a dominant-negative mutant approach.
T3 290-422 Sentence denotes To help elucidate further the mechanism by which ZAP-70 regulates these initial events, we used a dominant-negative mutant approach.
T4 423-557 Sentence denotes We overexpressed in the Jurkat T-cell line ZAP-70 mutated on Tyr-492 and Tyr-493 in the putative regulatory loop of its kinase domain.
T4 423-557 Sentence denotes We overexpressed in the Jurkat T-cell line ZAP-70 mutated on Tyr-492 and Tyr-493 in the putative regulatory loop of its kinase domain.
T5 558-769 Sentence denotes This mutant inhibited TCR-induced activation of nuclear factor of activated T cells by interfering with both intracellular calcium increase and Ras-regulated activation of extracellular signal-regulated kinases.
T5 558-769 Sentence denotes This mutant inhibited TCR-induced activation of nuclear factor of activated T cells by interfering with both intracellular calcium increase and Ras-regulated activation of extracellular signal-regulated kinases.
T6 770-895 Sentence denotes Moreover, TCR-induced phosphorylation of pp36-38, thought to play a role upstream of these pathways, was found to be reduced.
T6 770-895 Sentence denotes Moreover, TCR-induced phosphorylation of pp36-38, thought to play a role upstream of these pathways, was found to be reduced.
T7 896-1015 Sentence denotes In contrast, overexpression of wild-type ZAP-70 induced constitutive activation of nuclear factor of activated T cells.
T7 896-1015 Sentence denotes In contrast, overexpression of wild-type ZAP-70 induced constitutive activation of nuclear factor of activated T cells.
T8 1016-1151 Sentence denotes The ZAP-70 mutant studied here could be phosphorylated on tyrosine when associated to the TCR zeta chain and was able to bind p56(lck).
T8 1016-1151 Sentence denotes The ZAP-70 mutant studied here could be phosphorylated on tyrosine when associated to the TCR zeta chain and was able to bind p56(lck).
T9 1152-1297 Sentence denotes This result demonstrates that Tyr-492 and Tyr-493 are not responsible for the Src homology domain 2-mediated association of p56(lck) with ZAP-70.
T9 1152-1297 Sentence denotes This result demonstrates that Tyr-492 and Tyr-493 are not responsible for the Src homology domain 2-mediated association of p56(lck) with ZAP-70.
T10 1298-1543 Sentence denotes Our data are most consistent with a model in which recruitment to the TCR allows ZAP-70 autophosphorylation and binding to p56(lck), which in turn phosphorylates Tyr-492 and/or Tyr-493 with consequent up-regulation of the ZAP-70 kinase activity.
T10 1298-1543 Sentence denotes Our data are most consistent with a model in which recruitment to the TCR allows ZAP-70 autophosphorylation and binding to p56(lck), which in turn phosphorylates Tyr-492 and/or Tyr-493 with consequent up-regulation of the ZAP-70 kinase activity.
T11 1544-1654 Sentence denotes ZAP-70 will then be able to effectively control phosphorylation of its substrates and lead to gene activation.
T11 1544-1654 Sentence denotes ZAP-70 will then be able to effectively control phosphorylation of its substrates and lead to gene activation.