| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-106 |
Sentence |
denotes |
The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells. |
| T1 |
0-106 |
Sentence |
denotes |
The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells. |
| T2 |
107-258 |
Sentence |
denotes |
Interferon-gamma (IFN-gamma) is produced by natural killer cells and certain subsets of T cells, but the basis for its selective expression is unknown. |
| T2 |
107-258 |
Sentence |
denotes |
Interferon-gamma (IFN-gamma) is produced by natural killer cells and certain subsets of T cells, but the basis for its selective expression is unknown. |
| T3 |
259-443 |
Sentence |
denotes |
Within the region between -108 and -40 base pairs of the IFN-gamma promoter are two conserved and essential regulatory elements, which confer activation-specific expression in T cells. |
| T3 |
259-443 |
Sentence |
denotes |
Within the region between -108 and -40 base pairs of the IFN-gamma promoter are two conserved and essential regulatory elements, which confer activation-specific expression in T cells. |
| T4 |
444-598 |
Sentence |
denotes |
This report describes studies indicating that the most proximal of these two regulatory elements is an important determinant of its restricted expression. |
| T4 |
444-598 |
Sentence |
denotes |
This report describes studies indicating that the most proximal of these two regulatory elements is an important determinant of its restricted expression. |
| T5 |
599-728 |
Sentence |
denotes |
The proximal element is a composite site that binds members of the CREB/ATF, AP-1, and octamer families of transcription factors. |
| T5 |
599-728 |
Sentence |
denotes |
The proximal element is a composite site that binds members of the CREB/ATF, AP-1, and octamer families of transcription factors. |
| T6 |
729-832 |
Sentence |
denotes |
Jun is essential for activation-induced transcription and binds preferably as a heterodimer with ATF-2. |
| T6 |
729-832 |
Sentence |
denotes |
Jun is essential for activation-induced transcription and binds preferably as a heterodimer with ATF-2. |
| T7 |
833-901 |
Sentence |
denotes |
In contrast, CREB appears to dampen transcription from this element. |
| T7 |
833-901 |
Sentence |
denotes |
In contrast, CREB appears to dampen transcription from this element. |
| T8 |
902-1089 |
Sentence |
denotes |
The CpG dinucleotide in this element is selectively methylated in Th2 T cells and other cells that do not express IFN-gamma, and methylation markedly reduces transcription factor binding. |
| T8 |
902-1089 |
Sentence |
denotes |
The CpG dinucleotide in this element is selectively methylated in Th2 T cells and other cells that do not express IFN-gamma, and methylation markedly reduces transcription factor binding. |
| T9 |
1090-1281 |
Sentence |
denotes |
As a target for DNA methylation and for binding of transcription factors that mediate or impede transcription, this element appears to play a central role in controlling IFN-gamma expression. |
| T9 |
1090-1281 |
Sentence |
denotes |
As a target for DNA methylation and for binding of transcription factors that mediate or impede transcription, this element appears to play a central role in controlling IFN-gamma expression. |