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PubMed:8940179 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
T1 0-150 Sentence denotes Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
T2 151-337 Sentence denotes Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
T2 151-337 Sentence denotes Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
T3 338-462 Sentence denotes MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
T3 338-462 Sentence denotes MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
T4 463-587 Sentence denotes We report herein the isolation of a cDNA encoding a novel protein kinase designated MAPKKK5 from a human macrophage library.
T4 463-587 Sentence denotes We report herein the isolation of a cDNA encoding a novel protein kinase designated MAPKKK5 from a human macrophage library.
T5 588-714 Sentence denotes The nucleotide sequence predicts that MAPKKK5 encodes an open reading frame of 1374 amino acids with all 11 kinase subdomains.
T5 588-714 Sentence denotes The nucleotide sequence predicts that MAPKKK5 encodes an open reading frame of 1374 amino acids with all 11 kinase subdomains.
T6 715-978 Sentence denotes The putative catalytic domain of MAPKKK5 shows significant sequence homology to the kinase domains of the MAPKKK/MEKK level protein kinases from mouse MEKK2 and -3, Drosophila melanogaster PK92B, Saccharomyces cerevisiae STE11, and Schizosaccharomyces pombe BYR2.
T6 715-978 Sentence denotes The putative catalytic domain of MAPKKK5 shows significant sequence homology to the kinase domains of the MAPKKK/MEKK level protein kinases from mouse MEKK2 and -3, Drosophila melanogaster PK92B, Saccharomyces cerevisiae STE11, and Schizosaccharomyces pombe BYR2.
T7 979-1085 Sentence denotes Northern blot analysis showed that MAPKKK5 transcript is abundantly expressed in human heart and pancreas.
T7 979-1085 Sentence denotes Northern blot analysis showed that MAPKKK5 transcript is abundantly expressed in human heart and pancreas.
T8 1086-1239 Sentence denotes When transiently expressed in COS and 293 cells, MAPKKK5 markedly activated c-Jun N-terminal kinase or stress-activated protein kinase, but not MAPK/ERK.
T8 1086-1239 Sentence denotes When transiently expressed in COS and 293 cells, MAPKKK5 markedly activated c-Jun N-terminal kinase or stress-activated protein kinase, but not MAPK/ERK.
T9 1240-1470 Sentence denotes Furthermore, MAPKKK5 that was immunoprecipitated from transfected 293 cells was able to phosphorylate and activate MKK4 in vitro, suggesting that MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway.
T9 1240-1470 Sentence denotes Furthermore, MAPKKK5 that was immunoprecipitated from transfected 293 cells was able to phosphorylate and activate MKK4 in vitro, suggesting that MAPKKK5 may be an upstream activator of MKK4 in the c-Jun N-terminal kinase pathway.