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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-283 Sentence denotes Molecular dynamics-derived conformation and intramolecular interaction analysis of the N-acetyl-9-O-acetylneuraminic acid-containing ganglioside GD1a and NMR-based analysis of its binding to a human polyclonal immunoglobulin G fraction with selectivity for O-acetylated sialic acids.
T1 0-283 Sentence denotes Molecular dynamics-derived conformation and intramolecular interaction analysis of the N-acetyl-9-O-acetylneuraminic acid-containing ganglioside GD1a and NMR-based analysis of its binding to a human polyclonal immunoglobulin G fraction with selectivity for O-acetylated sialic acids.
T1 0-283 Sentence denotes Molecular dynamics-derived conformation and intramolecular interaction analysis of the N-acetyl-9-O-acetylneuraminic acid-containing ganglioside GD1a and NMR-based analysis of its binding to a human polyclonal immunoglobulin G fraction with selectivity for O-acetylated sialic acids.
TextSentencer_T2 284-556 Sentence denotes The influence of 9-O-acetylation of GD1a, yielding GD1a (eNeu5,9Ac2) with a 9-O-acetylated sialic acid moiety linked to the outer galactose residue, on the spatial extension and mobility of the carbohydrate chain and on recognition by a natural human antibody is analysed.
T2 284-556 Sentence denotes The influence of 9-O-acetylation of GD1a, yielding GD1a (eNeu5,9Ac2) with a 9-O-acetylated sialic acid moiety linked to the outer galactose residue, on the spatial extension and mobility of the carbohydrate chain and on recognition by a natural human antibody is analysed.
T2 284-556 Sentence denotes The influence of 9-O-acetylation of GD1a, yielding GD1a (eNeu5,9Ac2) with a 9-O-acetylated sialic acid moiety linked to the outer galactose residue, on the spatial extension and mobility of the carbohydrate chain and on recognition by a natural human antibody is analysed.
TextSentencer_T3 557-844 Sentence denotes To study a potential impact of the O-acetyl group on the overall conformation of the carbohydrate chain, molecular dynamics (MD) simulations of oligosaccharide chain fragments of increasing length starting from the non-reducing end have been carried out for the first time in this study.
T3 557-844 Sentence denotes To study a potential impact of the O-acetyl group on the overall conformation of the carbohydrate chain, molecular dynamics (MD) simulations of oligosaccharide chain fragments of increasing length starting from the non-reducing end have been carried out for the first time in this study.
T3 557-844 Sentence denotes To study a potential impact of the O-acetyl group on the overall conformation of the carbohydrate chain, molecular dynamics (MD) simulations of oligosaccharide chain fragments of increasing length starting from the non-reducing end have been carried out for the first time in this study.
TextSentencer_T4 845-970 Sentence denotes They revealed a considerable loss in chain flexibility after addition of the internal N-acetylneuraminic acid onto the chain.
T4 845-970 Sentence denotes They revealed a considerable loss in chain flexibility after addition of the internal N-acetylneuraminic acid onto the chain.
T4 845-970 Sentence denotes They revealed a considerable loss in chain flexibility after addition of the internal N-acetylneuraminic acid onto the chain.
TextSentencer_T5 971-1197 Sentence denotes Besides MD calculations with different dielectric constants, the conformational behaviour of the complete oligosaccharide chain of the 9-O-acetylated GD1a ganglioside was simulated in the solvents water and dimethyl sulfoxide.
T5 971-1197 Sentence denotes Besides MD calculations with different dielectric constants, the conformational behaviour of the complete oligosaccharide chain of the 9-O-acetylated GD1a ganglioside was simulated in the solvents water and dimethyl sulfoxide.
T5 971-1197 Sentence denotes Besides MD calculations with different dielectric constants, the conformational behaviour of the complete oligosaccharide chain of the 9-O-acetylated GD1a ganglioside was simulated in the solvents water and dimethyl sulfoxide.
TextSentencer_T6 1198-1248 Sentence denotes These solvents were also used in NMR measurements.
T6 1198-1248 Sentence denotes These solvents were also used in NMR measurements.
T6 1198-1248 Sentence denotes These solvents were also used in NMR measurements.
TextSentencer_T7 1249-1396 Sentence denotes The results of this study indicate that 9-O-acetylation at the terminal sialic acid does not influence the overall conformation of the ganglioside.
T7 1249-1396 Sentence denotes The results of this study indicate that 9-O-acetylation at the terminal sialic acid does not influence the overall conformation of the ganglioside.
T7 1249-1396 Sentence denotes The results of this study indicate that 9-O-acetylation at the terminal sialic acid does not influence the overall conformation of the ganglioside.
TextSentencer_T8 1397-1657 Sentence denotes An extended interaction analysis of energetically minimized conformations of GD1a (eNeu5,9Ac2) and GD1a, obtained during molecular dynamics simulations, allowed assessment of the influence of the different parts of the saccharide chains on spatial flexibility.
T8 1397-1657 Sentence denotes An extended interaction analysis of energetically minimized conformations of GD1a (eNeu5,9Ac2) and GD1a, obtained during molecular dynamics simulations, allowed assessment of the influence of the different parts of the saccharide chains on spatial flexibility.
T8 1397-1657 Sentence denotes An extended interaction analysis of energetically minimized conformations of GD1a (eNeu5,9Ac2) and GD1a, obtained during molecular dynamics simulations, allowed assessment of the influence of the different parts of the saccharide chains on spatial flexibility.
TextSentencer_T9 1658-1826 Sentence denotes Noteworthy energetic interactions, most interestingly between the 9-O-acetyl group and the pyranose ring of N-acetylgalactosamine, were ascertained by the calculations.
T9 1658-1826 Sentence denotes Noteworthy energetic interactions, most interestingly between the 9-O-acetyl group and the pyranose ring of N-acetylgalactosamine, were ascertained by the calculations.
T9 1658-1826 Sentence denotes Noteworthy energetic interactions, most interestingly between the 9-O-acetyl group and the pyranose ring of N-acetylgalactosamine, were ascertained by the calculations.
TextSentencer_T10 1827-1972 Sentence denotes However, the strength of this interaction does not force the ganglioside into a conformation, where the 9-O-acetyl group is no longer accessible.
T10 1827-1972 Sentence denotes However, the strength of this interaction does not force the ganglioside into a conformation, where the 9-O-acetyl group is no longer accessible.
T10 1827-1972 Sentence denotes However, the strength of this interaction does not force the ganglioside into a conformation, where the 9-O-acetyl group is no longer accessible.
TextSentencer_T11 1973-2140 Sentence denotes Binding of GD1a (eNeu5,9Ac2) to proteins, which are specific for 9-O-acetylated sialic acids, should thus at least partially be mediated by the presence of this group.
T11 1973-2140 Sentence denotes Binding of GD1a (eNeu5,9Ac2) to proteins, which are specific for 9-O-acetylated sialic acids, should thus at least partially be mediated by the presence of this group.
T11 1973-2140 Sentence denotes Binding of GD1a (eNeu5,9Ac2) to proteins, which are specific for 9-O-acetylated sialic acids, should thus at least partially be mediated by the presence of this group.
TextSentencer_T12 2141-2368 Sentence denotes To experimentally prove this assumption, a NMR study of 9-O-acetylated GD1a in the presence of an affinity-purified polyclonal IgG fraction from human serum with preferential binding to 9-O-acetylated sialic acid was performed.
T12 2141-2368 Sentence denotes To experimentally prove this assumption, a NMR study of 9-O-acetylated GD1a in the presence of an affinity-purified polyclonal IgG fraction from human serum with preferential binding to 9-O-acetylated sialic acid was performed.
T12 2141-2368 Sentence denotes To experimentally prove this assumption, a NMR study of 9-O-acetylated GD1a in the presence of an affinity-purified polyclonal IgG fraction from human serum with preferential binding to 9-O-acetylated sialic acid was performed.
TextSentencer_T13 2369-2583 Sentence denotes The almost complete disappearance of the intensity of the 9-O-acetyl methyl signal of the GD1a (eNeu5,9Ac2) clearly indicates that the assumed interaction of the 9-O-acetyl group with the human protein takes place.
T13 2369-2583 Sentence denotes The almost complete disappearance of the intensity of the 9-O-acetyl methyl signal of the GD1a (eNeu5,9Ac2) clearly indicates that the assumed interaction of the 9-O-acetyl group with the human protein takes place.
T13 2369-2583 Sentence denotes The almost complete disappearance of the intensity of the 9-O-acetyl methyl signal of the GD1a (eNeu5,9Ac2) clearly indicates that the assumed interaction of the 9-O-acetyl group with the human protein takes place.