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PubMed:8824290 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase.
T1 0-144 Sentence denotes Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase.
T2 145-355 Sentence denotes The growth-promoting effects of gastrin on normal and neoplastic gastrointestinal tissues have been shown to be mediated by the gastrin/CCKB receptor, which belongs to the family of G protein-coupled receptors.
T2 145-355 Sentence denotes The growth-promoting effects of gastrin on normal and neoplastic gastrointestinal tissues have been shown to be mediated by the gastrin/CCKB receptor, which belongs to the family of G protein-coupled receptors.
T3 356-447 Sentence denotes However, the downstream signaling pathways activated by gastrin are not well characterized.
T3 356-447 Sentence denotes However, the downstream signaling pathways activated by gastrin are not well characterized.
T4 448-631 Sentence denotes In the present study, we demonstrate that gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), the major cytoplasmic substrate of the insulin receptor.
T4 448-631 Sentence denotes In the present study, we demonstrate that gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), the major cytoplasmic substrate of the insulin receptor.
T5 632-764 Sentence denotes The gastrin-induced phosphorylation of IRS-1 was rapid and transient, occurring within 30 s of treatment and diminishing thereafter.
T5 632-764 Sentence denotes The gastrin-induced phosphorylation of IRS-1 was rapid and transient, occurring within 30 s of treatment and diminishing thereafter.
T6 765-880 Sentence denotes IRS-1 binds several proteins containing Src homology 2 domains through its multiple tyrosine phosphorylation sites.
T6 765-880 Sentence denotes IRS-1 binds several proteins containing Src homology 2 domains through its multiple tyrosine phosphorylation sites.
T7 881-1051 Sentence denotes Following gastrin stimulation, we observed a time- and dose-dependent association of IRS-1 with the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI 3-kinase).
T7 881-1051 Sentence denotes Following gastrin stimulation, we observed a time- and dose-dependent association of IRS-1 with the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI 3-kinase).
T8 1052-1324 Sentence denotes In addition, activation of PI 3-kinase was detected in anti-IRS-1 immunoprecipitates from gastrin-treated cells, suggesting that tyrosine phosphorylation of IRS-1, which leads to the rapid recruitment of p85, might be one mechanism used by gastrin to activate PI 3-kinase.
T8 1052-1324 Sentence denotes In addition, activation of PI 3-kinase was detected in anti-IRS-1 immunoprecipitates from gastrin-treated cells, suggesting that tyrosine phosphorylation of IRS-1, which leads to the rapid recruitment of p85, might be one mechanism used by gastrin to activate PI 3-kinase.
T9 1325-1528 Sentence denotes We have previously reported that tyrosine phosphorylation of Shc and its association with the Grb2-Sos complex may contribute to the activation of the mitogen-activated protein kinase pathway by gastrin.
T9 1325-1528 Sentence denotes We have previously reported that tyrosine phosphorylation of Shc and its association with the Grb2-Sos complex may contribute to the activation of the mitogen-activated protein kinase pathway by gastrin.
T10 1529-1627 Sentence denotes We report here that Grb2 also interacts with tyrosine-phosphorylated IRS-1 in response to gastrin.
T10 1529-1627 Sentence denotes We report here that Grb2 also interacts with tyrosine-phosphorylated IRS-1 in response to gastrin.
T11 1628-1870 Sentence denotes Taken together, our results suggest that IRS-1 may serve as a converging target in the signaling pathways stimulated by receptors that belong to different families, such as the gastrin/CCKB G protein-coupled receptor and the insulin receptor.
T11 1628-1870 Sentence denotes Taken together, our results suggest that IRS-1 may serve as a converging target in the signaling pathways stimulated by receptors that belong to different families, such as the gastrin/CCKB G protein-coupled receptor and the insulin receptor.