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Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells.
T1 0-126 Sentence denotes Phosphatidylinositol 3-kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells.
T2 127-248 Sentence denotes Phosphatidylinositol (PI) 3-kinase is an important enzyme implicated in growth factor-stimulated intracellular signaling.
T2 127-248 Sentence denotes Phosphatidylinositol (PI) 3-kinase is an important enzyme implicated in growth factor-stimulated intracellular signaling.
T3 249-433 Sentence denotes In this study we have shown that hepatocyte growth factor (HGF) induces a rapid tyrosine phosphorylation of PI 3-kinase and association with HGF receptor/Met in Mv1Lu epithelial cells.
T3 249-433 Sentence denotes In this study we have shown that hepatocyte growth factor (HGF) induces a rapid tyrosine phosphorylation of PI 3-kinase and association with HGF receptor/Met in Mv1Lu epithelial cells.
T4 434-563 Sentence denotes Murine mammary carcinoma (SP1) cells, which co-express HGF and HGF receptor/Met, showed sustained phosphorylation of PI 3-kinase.
T4 434-563 Sentence denotes Murine mammary carcinoma (SP1) cells, which co-express HGF and HGF receptor/Met, showed sustained phosphorylation of PI 3-kinase.
T5 564-759 Sentence denotes Wortmannin, a potent inhibitor of PI 3-kinase, inhibited HGF-induced PI 3-kinase activity, proliferation of Mv1Lu cells, and spontaneous growth of SP1 cells in a dose-, and time-dependent manner.
T5 564-759 Sentence denotes Wortmannin, a potent inhibitor of PI 3-kinase, inhibited HGF-induced PI 3-kinase activity, proliferation of Mv1Lu cells, and spontaneous growth of SP1 cells in a dose-, and time-dependent manner.
T6 760-929 Sentence denotes Transfection of a dominant negative mutant p85 (Deltap85) subunit of PI 3-kinase into SP1 cells strongly inhibited HGF-stimulated proliferation and PI 3-kinase activity.
T6 760-929 Sentence denotes Transfection of a dominant negative mutant p85 (Deltap85) subunit of PI 3-kinase into SP1 cells strongly inhibited HGF-stimulated proliferation and PI 3-kinase activity.
T7 930-997 Sentence denotes However, wortmannin did not influence HGF-induced c-Jun expression.
T7 930-997 Sentence denotes However, wortmannin did not influence HGF-induced c-Jun expression.
T8 998-1110 Sentence denotes Furthermore, HGF stimulated S6 kinase activity, but its activity was not required for HGF-induced proliferation.
T8 998-1110 Sentence denotes Furthermore, HGF stimulated S6 kinase activity, but its activity was not required for HGF-induced proliferation.
T9 1111-1350 Sentence denotes Overall, these results suggest that HGF-induced PI 3-kinase activity is important for the mitogenic action of HGF in epithelial cells and further demonstrate that expression of c-Jun is not influenced by inhibition of PI 3-kinase activity.
T9 1111-1350 Sentence denotes Overall, these results suggest that HGF-induced PI 3-kinase activity is important for the mitogenic action of HGF in epithelial cells and further demonstrate that expression of c-Jun is not influenced by inhibition of PI 3-kinase activity.