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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-161 Sentence denotes Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties.
T1 0-161 Sentence denotes Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties.
T1 0-161 Sentence denotes Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties.
TextSentencer_T2 162-399 Sentence denotes Structural features of heparin potentially important for heparanase-inhibitory activity were examined by measuring the ability of heparin derivatives to affect the degradation of [3H]acetylated heparan sulphate by tumor cell heparanases.
T2 162-399 Sentence denotes Structural features of heparin potentially important for heparanase-inhibitory activity were examined by measuring the ability of heparin derivatives to affect the degradation of [3H]acetylated heparan sulphate by tumor cell heparanases.
T2 162-399 Sentence denotes Structural features of heparin potentially important for heparanase-inhibitory activity were examined by measuring the ability of heparin derivatives to affect the degradation of [3H]acetylated heparan sulphate by tumor cell heparanases.
TextSentencer_T3 400-565 Sentence denotes IC50 values were determined using an assay which distinguished degraded from undegraded substrate by precipitation of the latter with cetylpyridinium chloride (CPC).
T3 400-565 Sentence denotes IC50 values were determined using an assay which distinguished degraded from undegraded substrate by precipitation of the latter with cetylpyridinium chloride (CPC).
T3 400-565 Sentence denotes IC50 values were determined using an assay which distinguished degraded from undegraded substrate by precipitation of the latter with cetylpyridinium chloride (CPC).
TextSentencer_T4 566-670 Sentence denotes Removal of heparin's 2-O-sulphate and 3-O-sulphate groups enhanced heparanase-inhibitory activity (50%).
T4 566-670 Sentence denotes Removal of heparin's 2-O-sulphate and 3-O-sulphate groups enhanced heparanase-inhibitory activity (50%).
T4 566-670 Sentence denotes Removal of heparin's 2-O-sulphate and 3-O-sulphate groups enhanced heparanase-inhibitory activity (50%).
TextSentencer_T5 671-793 Sentence denotes Removal of its carboxyl groups slightly lowered the activity (18%), while combining the treatments abolished the activity.
T5 671-793 Sentence denotes Removal of its carboxyl groups slightly lowered the activity (18%), while combining the treatments abolished the activity.
T5 671-793 Sentence denotes Removal of its carboxyl groups slightly lowered the activity (18%), while combining the treatments abolished the activity.
TextSentencer_T6 794-917 Sentence denotes At least one negative charge on the iduronic acid/idose moiety, therefore, is necessary for heparanase-inhibitory activity.
T6 794-917 Sentence denotes At least one negative charge on the iduronic acid/idose moiety, therefore, is necessary for heparanase-inhibitory activity.
T6 794-917 Sentence denotes At least one negative charge on the iduronic acid/idose moiety, therefore, is necessary for heparanase-inhibitory activity.
TextSentencer_T7 918-1004 Sentence denotes Replacing heparin's N-sulphate groups with N-acetyl groups reduced its activity (37%).
T7 918-1004 Sentence denotes Replacing heparin's N-sulphate groups with N-acetyl groups reduced its activity (37%).
T7 918-1004 Sentence denotes Replacing heparin's N-sulphate groups with N-acetyl groups reduced its activity (37%).
TextSentencer_T8 1005-1203 Sentence denotes Comparing this heparin derivative with 2,3-O-desulphated heparin, the placement of sulphate groups appears important for activity since the two structures have similar nominal linear charge density.
T8 1005-1203 Sentence denotes Comparing this heparin derivative with 2,3-O-desulphated heparin, the placement of sulphate groups appears important for activity since the two structures have similar nominal linear charge density.
T8 1005-1203 Sentence denotes Comparing this heparin derivative with 2,3-O-desulphated heparin, the placement of sulphate groups appears important for activity since the two structures have similar nominal linear charge density.
TextSentencer_T9 1204-1405 Sentence denotes In addition, unsubstituted uronic acids are nonessential for inhibition since their modification (periodate-oxidation/borohydride-reduction) enhanced rather than reduced heparanase-inhibitory activity.
T9 1204-1405 Sentence denotes In addition, unsubstituted uronic acids are nonessential for inhibition since their modification (periodate-oxidation/borohydride-reduction) enhanced rather than reduced heparanase-inhibitory activity.
T9 1204-1405 Sentence denotes In addition, unsubstituted uronic acids are nonessential for inhibition since their modification (periodate-oxidation/borohydride-reduction) enhanced rather than reduced heparanase-inhibitory activity.
TextSentencer_T10 1406-1675 Sentence denotes The most effective heparanase inhibitors (2,3-O-desulphated heparin, and [periodate-oxidized, borohydride-reduced] heparin) were tested in the chick chorioallantoic membrane (CAM) bioassay for anti-angiogenic activity and found to be at least as efficacious as heparin.
T10 1406-1675 Sentence denotes The most effective heparanase inhibitors (2,3-O-desulphated heparin, and [periodate-oxidized, borohydride-reduced] heparin) were tested in the chick chorioallantoic membrane (CAM) bioassay for anti-angiogenic activity and found to be at least as efficacious as heparin.
T10 1406-1675 Sentence denotes The most effective heparanase inhibitors (2,3-O-desulphated heparin, and [periodate-oxidized, borohydride-reduced] heparin) were tested in the chick chorioallantoic membrane (CAM) bioassay for anti-angiogenic activity and found to be at least as efficacious as heparin.
TextSentencer_T11 1676-1929 Sentence denotes 2,3-O-desulphated heparin also significantly decreased the tumor growth of a subcutaneous human pancreatic (Ca-Pan-2) adenocarcinoma in nude mice and prolonged the survival times of C57BL/6N mice in a B16-F10 melanoma experimental lung metastasis assay.
T11 1676-1929 Sentence denotes 2,3-O-desulphated heparin also significantly decreased the tumor growth of a subcutaneous human pancreatic (Ca-Pan-2) adenocarcinoma in nude mice and prolonged the survival times of C57BL/6N mice in a B16-F10 melanoma experimental lung metastasis assay.
T11 1676-1929 Sentence denotes 2,3-O-desulphated heparin also significantly decreased the tumor growth of a subcutaneous human pancreatic (Ca-Pan-2) adenocarcinoma in nude mice and prolonged the survival times of C57BL/6N mice in a B16-F10 melanoma experimental lung metastasis assay.