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Id Subject Object Predicate Lexical cue
T1 0-44 Sentence denotes Isocitrate dehydrogenase kinase/phosphatase.
T1 0-44 Sentence denotes Isocitrate dehydrogenase kinase/phosphatase.
T2 45-110 Sentence denotes Kinetic characteristics of the wild-type and two mutant proteins.
T2 45-110 Sentence denotes Kinetic characteristics of the wild-type and two mutant proteins.
T3 111-225 Sentence denotes Isocitrate dehydrogenase (IDH) of Escherichia coli is regulated by a bifunctional protein, IDH kinase/phosphatase.
T3 111-225 Sentence denotes Isocitrate dehydrogenase (IDH) of Escherichia coli is regulated by a bifunctional protein, IDH kinase/phosphatase.
T4 226-332 Sentence denotes In addition to the kinase and phosphatase activities, this protein catalyzes an intrinsic ATPase reaction.
T4 226-332 Sentence denotes In addition to the kinase and phosphatase activities, this protein catalyzes an intrinsic ATPase reaction.
T5 333-416 Sentence denotes The initial velocity kinetics of these activities exhibited extensive similarities.
T5 333-416 Sentence denotes The initial velocity kinetics of these activities exhibited extensive similarities.
T6 417-494 Sentence denotes IDH kinase and phosphatase both yielded intersecting double-reciprocal plots.
T6 417-494 Sentence denotes IDH kinase and phosphatase both yielded intersecting double-reciprocal plots.
T7 495-699 Sentence denotes In addition, we observed similar values for the kinetic constants describing interactions of the kinase and phosphatase with their protein substrates and the interactions of all three activities with ATP.
T7 495-699 Sentence denotes In addition, we observed similar values for the kinetic constants describing interactions of the kinase and phosphatase with their protein substrates and the interactions of all three activities with ATP.
T8 700-858 Sentence denotes In contrast, while the maximum velocities of IDH kinase and IDH phosphatase were nearly equal, they were 10-fold less than the maximum velocity of the ATPase.
T8 700-858 Sentence denotes In contrast, while the maximum velocities of IDH kinase and IDH phosphatase were nearly equal, they were 10-fold less than the maximum velocity of the ATPase.
T9 859-1011 Sentence denotes Although the IDH phosphatase reaction required either ATP or ADP, it was not supported by the nonhydrolyzable ATP analogue 5'-adenylyl imidodiphosphate.
T9 859-1011 Sentence denotes Although the IDH phosphatase reaction required either ATP or ADP, it was not supported by the nonhydrolyzable ATP analogue 5'-adenylyl imidodiphosphate.
T10 1012-1138 Sentence denotes The kinetic properties of wild-type IDH kinase/phosphatase were compared with those of two mutant derivatives of this protein.
T10 1012-1138 Sentence denotes The kinetic properties of wild-type IDH kinase/phosphatase were compared with those of two mutant derivatives of this protein.
T11 1139-1216 Sentence denotes The mutations in these proteins selectively inhibit IDH phosphatase activity.
T11 1139-1216 Sentence denotes The mutations in these proteins selectively inhibit IDH phosphatase activity.
T12 1217-1400 Sentence denotes Inhibition of IDH phosphatase resulted from three factors: decreases in the maximum velocities, reduced affinities for phospho-IDH, and a loss of coupling between ATP and phospho-IDH.
T12 1217-1400 Sentence denotes Inhibition of IDH phosphatase resulted from three factors: decreases in the maximum velocities, reduced affinities for phospho-IDH, and a loss of coupling between ATP and phospho-IDH.
T13 1401-1549 Sentence denotes These mutations also affected the properties of IDH kinase, increasing the maximum velocities and decreasing the affinities for ATP and phospho-IDH.
T13 1401-1549 Sentence denotes These mutations also affected the properties of IDH kinase, increasing the maximum velocities and decreasing the affinities for ATP and phospho-IDH.
T14 1550-1622 Sentence denotes The intrinsic ATPase activities also exhibited reduced affinity for ATP.
T14 1550-1622 Sentence denotes The intrinsic ATPase activities also exhibited reduced affinity for ATP.
T15 1623-1748 Sentence denotes These results are discussed in the context of a model which proposes that all three activities occur at the same active site.
T15 1623-1748 Sentence denotes These results are discussed in the context of a model which proposes that all three activities occur at the same active site.