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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-190 Sentence denotes Undersulfation of proteoglycans synthesized by chondrocytes from a patient with achondrogenesis type 1B homozygous for an L483P substitution in the diastrophic dysplasia sulfate transporter.
T1 0-190 Sentence denotes Undersulfation of proteoglycans synthesized by chondrocytes from a patient with achondrogenesis type 1B homozygous for an L483P substitution in the diastrophic dysplasia sulfate transporter.
TextSentencer_T2 191-403 Sentence denotes Achondrogenesis type 1B is an autosomal recessive, lethal chondrodysplasia caused by mutations in the gene encoding a sulfate/chloride antiporter of the cell membrane (Superti-Furga, A., Hästbacka, J., Wilcox, W.
T2 191-403 Sentence denotes Achondrogenesis type 1B is an autosomal recessive, lethal chondrodysplasia caused by mutations in the gene encoding a sulfate/chloride antiporter of the cell membrane (Superti-Furga, A., Hästbacka, J., Wilcox, W.
TextSentencer_T3 404-416 Sentence denotes R., Cohn, D.
T3 404-416 Sentence denotes R., Cohn, D.
TextSentencer_T4 417-439 Sentence denotes H., van der Harten, J.
T4 417-439 Sentence denotes H., van der Harten, J.
TextSentencer_T5 440-475 Sentence denotes J., Rossi, A., Blau, N., Rimoin, D.
T5 440-475 Sentence denotes J., Rossi, A., Blau, N., Rimoin, D.
TextSentencer_T6 476-505 Sentence denotes L., Steinmann, B., Lander, E.
T6 476-505 Sentence denotes L., Steinmann, B., Lander, E.
TextSentencer_T7 506-539 Sentence denotes S., and Gitzelmann, R.(1996) Nat.
T7 506-539 Sentence denotes S., and Gitzelmann, R.(1996) Nat.
TextSentencer_T8 540-546 Sentence denotes Genet.
T8 540-546 Sentence denotes Genet.
TextSentencer_T9 547-560 Sentence denotes 12, 100-102).
T9 547-560 Sentence denotes 12, 100-102).
TextSentencer_T10 561-806 Sentence denotes To ascertain the consequences of the sulfate transport defect on proteoglycan synthesis, we studied the structure and sulfation of proteoglycans in cartilage tissue and in fibroblast and chondrocyte cultures from a fetus with achondrogenesis 1B.
T10 561-806 Sentence denotes To ascertain the consequences of the sulfate transport defect on proteoglycan synthesis, we studied the structure and sulfation of proteoglycans in cartilage tissue and in fibroblast and chondrocyte cultures from a fetus with achondrogenesis 1B.
TextSentencer_T11 807-958 Sentence denotes Proteoglycans extracted from epiphyseal cartilage and separated on agarose gels migrated more slowly than controls and stained poorly with alcian blue.
T11 807-958 Sentence denotes Proteoglycans extracted from epiphyseal cartilage and separated on agarose gels migrated more slowly than controls and stained poorly with alcian blue.
TextSentencer_T12 959-1159 Sentence denotes The patient's cultured cells showed reduced incorporation of [35S]sulfate relative to [3H]glucosamine, impaired uptake of sulfate, and higher resistance to chromate toxicity compared to control cells.
T12 959-1159 Sentence denotes The patient's cultured cells showed reduced incorporation of [35S]sulfate relative to [3H]glucosamine, impaired uptake of sulfate, and higher resistance to chromate toxicity compared to control cells.
TextSentencer_T13 1160-1411 Sentence denotes Epiphyseal chondrocytes cultured in alginate beads synthesized proteoglycans of normal molecular size as judged by gel filtration chromatography, but undersulfated as judged by ion exchange chromatography and by the amount of nonsulfated disaccharide.
T13 1160-1411 Sentence denotes Epiphyseal chondrocytes cultured in alginate beads synthesized proteoglycans of normal molecular size as judged by gel filtration chromatography, but undersulfated as judged by ion exchange chromatography and by the amount of nonsulfated disaccharide.
TextSentencer_T14 1412-1687 Sentence denotes High performance liquid chromatography analysis of chondroitinase-digested proteoglycans showed that sulfated disaccharides were present, although in reduced amounts, indicating that at least in vitro, other sources of sulfate can partially compensate for sulfate deficiency.
T14 1412-1687 Sentence denotes High performance liquid chromatography analysis of chondroitinase-digested proteoglycans showed that sulfated disaccharides were present, although in reduced amounts, indicating that at least in vitro, other sources of sulfate can partially compensate for sulfate deficiency.
TextSentencer_T15 1688-1901 Sentence denotes A t1475c transition causing a L483P substitution in the eleventh transmembrane domain of the sulfate/chloride antiporter was present on both alleles in the patient who was the product of a consanguineous marriage.
T15 1688-1901 Sentence denotes A t1475c transition causing a L483P substitution in the eleventh transmembrane domain of the sulfate/chloride antiporter was present on both alleles in the patient who was the product of a consanguineous marriage.
TextSentencer_T16 1902-2136 Sentence denotes The results indicate that the defect of sulfate transport is expressed in both chondrocytes and fibroblasts and results in the synthesis of proteoglycans bearing glycosaminoglycan chains which are poorly sulfated but of normal length.
T16 1902-2136 Sentence denotes The results indicate that the defect of sulfate transport is expressed in both chondrocytes and fibroblasts and results in the synthesis of proteoglycans bearing glycosaminoglycan chains which are poorly sulfated but of normal length.