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PubMed:8663148 JSONTXT 31 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
T1 0-144 Sentence denotes A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
T2 145-303 Sentence denotes XPB is a subunit of the basal transcription factor TFIIH, which is also involved in nucleotide excision repair (NER) and potentially in cell cycle regulation.
T2 145-303 Sentence denotes XPB is a subunit of the basal transcription factor TFIIH, which is also involved in nucleotide excision repair (NER) and potentially in cell cycle regulation.
T3 304-463 Sentence denotes A frameshift mutation in the 3'-end of the XPB gene is responsible for a concurrence of two disorders: xeroderma pigmentosum (XP) and Cockayne's syndrome (CS).
T3 304-463 Sentence denotes A frameshift mutation in the 3'-end of the XPB gene is responsible for a concurrence of two disorders: xeroderma pigmentosum (XP) and Cockayne's syndrome (CS).
T4 464-682 Sentence denotes We have isolated TFIIH from cells derived from a patient (XP11BE) who carries this frameshift mutation (TFIIHmut) and from the mother of this patient (TFIIHwt) to determine the biochemical consequences of the mutation.
T4 464-682 Sentence denotes We have isolated TFIIH from cells derived from a patient (XP11BE) who carries this frameshift mutation (TFIIHmut) and from the mother of this patient (TFIIHwt) to determine the biochemical consequences of the mutation.
T5 683-804 Sentence denotes Although identical in composition and stoichiometry to TFIIHwt, TFIIHmut shows a reduced 3' --> 5' XPB helicase activity.
T5 683-804 Sentence denotes Although identical in composition and stoichiometry to TFIIHwt, TFIIHmut shows a reduced 3' --> 5' XPB helicase activity.
T6 805-923 Sentence denotes A decrease in helicase and DNA-dependent ATPase activities was also observed with the mutated recombinant XPB protein.
T6 805-923 Sentence denotes A decrease in helicase and DNA-dependent ATPase activities was also observed with the mutated recombinant XPB protein.
T7 924-968 Sentence denotes The XPB mutation causes a severe NER defect.
T7 924-968 Sentence denotes The XPB mutation causes a severe NER defect.
T8 969-1058 Sentence denotes In addition, we provide evidence for a decrease in basal transcription activity in vitro.
T8 969-1058 Sentence denotes In addition, we provide evidence for a decrease in basal transcription activity in vitro.
T9 1059-1203 Sentence denotes The latter defect may provide an explanation for many of the XP and CS symptoms that are difficult to rationalize based solely on an NER defect.
T9 1059-1203 Sentence denotes The latter defect may provide an explanation for many of the XP and CS symptoms that are difficult to rationalize based solely on an NER defect.
T10 1204-1457 Sentence denotes Thus, this work presents the first detailed analysis of a naturally occurring mutation in a basal transcription factor and supports the concept that the combined XP/CS clinical entity is actually the result of a combined transcription/repair deficiency.
T10 1204-1457 Sentence denotes Thus, this work presents the first detailed analysis of a naturally occurring mutation in a basal transcription factor and supports the concept that the combined XP/CS clinical entity is actually the result of a combined transcription/repair deficiency.