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PubMed:8662939 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Identification of a critical ligand binding determinant of the human erythropoietin receptor.
T1 0-93 Sentence denotes Identification of a critical ligand binding determinant of the human erythropoietin receptor.
T2 94-168 Sentence denotes Evidence for common ligand binding motifs in the cytokine receptor family.
T2 94-168 Sentence denotes Evidence for common ligand binding motifs in the cytokine receptor family.
T3 169-345 Sentence denotes The erythropoietin receptor (EPOR) is a member of a family of cytokine and growth factor receptors that share conserved features in their extracellular and cytoplasmic domains.
T3 169-345 Sentence denotes The erythropoietin receptor (EPOR) is a member of a family of cytokine and growth factor receptors that share conserved features in their extracellular and cytoplasmic domains.
T4 346-504 Sentence denotes We have used site-specific mutagenesis within the extracellular domain of the EPOR to search for amino acid residues involved in erythropoietin (EPO) binding.
T4 346-504 Sentence denotes We have used site-specific mutagenesis within the extracellular domain of the EPOR to search for amino acid residues involved in erythropoietin (EPO) binding.
T5 505-661 Sentence denotes Mutant proteins were expressed in bacteria as soluble EPO binding proteins (EBP) and characterized for EPO binding activity in a number of different assays.
T5 505-661 Sentence denotes Mutant proteins were expressed in bacteria as soluble EPO binding proteins (EBP) and characterized for EPO binding activity in a number of different assays.
T6 662-802 Sentence denotes Substitution of phenylalanine at position 93 (Phe93) with alanine (F93A mutation) resulted in a drastic reduction in EPO binding in the EBP.
T6 662-802 Sentence denotes Substitution of phenylalanine at position 93 (Phe93) with alanine (F93A mutation) resulted in a drastic reduction in EPO binding in the EBP.
T7 803-921 Sentence denotes More conservative tyrosine or tryptophan substitutions at Phe93 resulted in much less dramatic effects on EPO binding.
T7 803-921 Sentence denotes More conservative tyrosine or tryptophan substitutions at Phe93 resulted in much less dramatic effects on EPO binding.
T8 922-1034 Sentence denotes Biophysical studies indicated that the F93A mutation does not result in gross structural alterations in the EBP.
T8 922-1034 Sentence denotes Biophysical studies indicated that the F93A mutation does not result in gross structural alterations in the EBP.
T9 1035-1142 Sentence denotes Furthermore, the F93A mutation in full-length EPOR expressed in COS cells abolished detectable EPO binding.
T9 1035-1142 Sentence denotes Furthermore, the F93A mutation in full-length EPOR expressed in COS cells abolished detectable EPO binding.
T10 1143-1263 Sentence denotes This was not a result of processing or transport defects, since mutant receptor was present on the surface of the cells.
T10 1143-1263 Sentence denotes This was not a result of processing or transport defects, since mutant receptor was present on the surface of the cells.
T11 1264-1463 Sentence denotes Mutations in the region immediately around Phe93 and in residues homologous to other reported ligand binding determinants of the cytokine receptor family had small to moderate effects on EPO binding.
T11 1264-1463 Sentence denotes Mutations in the region immediately around Phe93 and in residues homologous to other reported ligand binding determinants of the cytokine receptor family had small to moderate effects on EPO binding.
T12 1464-1545 Sentence denotes These data indicate that Phe93 is a critical EPO binding determinant of the EPOR.
T12 1464-1545 Sentence denotes These data indicate that Phe93 is a critical EPO binding determinant of the EPOR.
T13 1546-1784 Sentence denotes Furthermore, since Phe93 aligns with critical ligand binding determinants in other receptors of the cytokine receptor family, these data suggest that receptors of this family may use common structural motifs to bind their cognate ligands.
T13 1546-1784 Sentence denotes Furthermore, since Phe93 aligns with critical ligand binding determinants in other receptors of the cytokine receptor family, these data suggest that receptors of this family may use common structural motifs to bind their cognate ligands.