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PubMed:8662595 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists.
T1 0-111 Sentence denotes Characterization of the receptor binding sites of human leukemia inhibitory factor and creation of antagonists.
T2 112-345 Sentence denotes Residues in human leukemia inhibitory factor (hLIF) crucial for binding to both the human LIF receptor (R) and gp130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity.
T2 112-345 Sentence denotes Residues in human leukemia inhibitory factor (hLIF) crucial for binding to both the human LIF receptor (R) and gp130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity.
T3 346-517 Sentence denotes The region of hLIF most important for binding to the hLIF-R is composed of residues from the amino terminus of the D-helix, carboxyl terminus of the B-helix, and C-D loop.
T3 346-517 Sentence denotes The region of hLIF most important for binding to the hLIF-R is composed of residues from the amino terminus of the D-helix, carboxyl terminus of the B-helix, and C-D loop.
T4 518-649 Sentence denotes This site forms a distinct surface at the end of the four-helix bundle in the tertiary structure of the closely related murine LIF.
T4 518-649 Sentence denotes This site forms a distinct surface at the end of the four-helix bundle in the tertiary structure of the closely related murine LIF.
T5 650-826 Sentence denotes The two residues of hLIF that contribute the majority of free energy for hLIF-R binding, Phe-156 and Lys-159 are surrounded by other residues which have only a moderate impact.
T5 650-826 Sentence denotes The two residues of hLIF that contribute the majority of free energy for hLIF-R binding, Phe-156 and Lys-159 are surrounded by other residues which have only a moderate impact.
T6 827-988 Sentence denotes This arrangement of a few key residues surrounded by less important ones is analogous to the functional binding epitope of human growth hormone for its receptor.
T6 827-988 Sentence denotes This arrangement of a few key residues surrounded by less important ones is analogous to the functional binding epitope of human growth hormone for its receptor.
T7 989-1135 Sentence denotes A second region of hLIF that includes residues from the carboxyl terminus of the D-helix and A-B loop also had a weak influence on hLIF-R binding.
T7 989-1135 Sentence denotes A second region of hLIF that includes residues from the carboxyl terminus of the D-helix and A-B loop also had a weak influence on hLIF-R binding.
T8 1136-1230 Sentence denotes Residues in hLIF from both the A- and C-helices are involved in binding the gp130 co-receptor.
T8 1136-1230 Sentence denotes Residues in hLIF from both the A- and C-helices are involved in binding the gp130 co-receptor.
T9 1231-1309 Sentence denotes Abolition of the gp130 binding site in hLIF created antagonists of LIF action.
T9 1231-1309 Sentence denotes Abolition of the gp130 binding site in hLIF created antagonists of LIF action.