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PubMed:8631981 JSONTXT 40 Projects

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Id Subject Object Predicate Lexical cue
T1 0-43 Sentence denotes Expression cloning of a human GT3 synthase.
T1 0-43 Sentence denotes Expression cloning of a human GT3 synthase.
T2 44-91 Sentence denotes GD3 AND GT3 are synthesized by a single enzyme.
T2 44-91 Sentence denotes GD3 AND GT3 are synthesized by a single enzyme.
T3 92-216 Sentence denotes Gangliosides of the C series such as GT3 are polysialylated glycosphingolipids whose synthesis is developmentally regulated.
T3 92-216 Sentence denotes Gangliosides of the C series such as GT3 are polysialylated glycosphingolipids whose synthesis is developmentally regulated.
T4 217-493 Sentence denotes Here we report the expression cDNA cloning and characterization of GT3 synthase that adds the second alpha-2,8-sialic acid to GD3, NeuNAcalpha2-->8NeuNAcalpha2-->3Galbeta1-->4Glc-->Cer, thus forming GT3, NeuNAcalpha2-->8NeuNAcalpha2-->8NeuNAc alpha2-->3Galbeta1--> 4Glc-->Cer.
T4 217-493 Sentence denotes Here we report the expression cDNA cloning and characterization of GT3 synthase that adds the second alpha-2,8-sialic acid to GD3, NeuNAcalpha2-->8NeuNAcalpha2-->3Galbeta1-->4Glc-->Cer, thus forming GT3, NeuNAcalpha2-->8NeuNAcalpha2-->8NeuNAc alpha2-->3Galbeta1--> 4Glc-->Cer.
T5 494-588 Sentence denotes Unexpectedly, the cloned cDNA was found to be identical to the cDNA that encodes GD3 synthase.
T5 494-588 Sentence denotes Unexpectedly, the cloned cDNA was found to be identical to the cDNA that encodes GD3 synthase.
T6 589-666 Sentence denotes The newly identified enzyme was therefore named GD3/GT3 synthase (GD3/GT3ST).
T6 589-666 Sentence denotes The newly identified enzyme was therefore named GD3/GT3 synthase (GD3/GT3ST).
T7 667-932 Sentence denotes GD3/GT3ST synthesized GT3 most efficiently when GM3, NeuNAcalpha2-->3Galbeta1-->4Glc-->Cer, was incubated as an acceptor, indicating that GD3/GT3ST is a polysialyltransferase that can transfer more than one sialic acid residue via alpha-2,8 linkage to gangliosides.
T7 667-932 Sentence denotes GD3/GT3ST synthesized GT3 most efficiently when GM3, NeuNAcalpha2-->3Galbeta1-->4Glc-->Cer, was incubated as an acceptor, indicating that GD3/GT3ST is a polysialyltransferase that can transfer more than one sialic acid residue via alpha-2,8 linkage to gangliosides.
T8 933-1065 Sentence denotes Moreover, a longer period of incubation of GD3 with GD3/GT3ST produced a significant amount of GT3 and higher polysialogangliosides.
T8 933-1065 Sentence denotes Moreover, a longer period of incubation of GD3 with GD3/GT3ST produced a significant amount of GT3 and higher polysialogangliosides.
T9 1066-1243 Sentence denotes Among various cell lines expressing GD3/GT3ST, higher polysialogangliosides including GT3 were detected only in cell lines where the amount of GD3/GT3 mRNA is sufficiently high.
T9 1066-1243 Sentence denotes Among various cell lines expressing GD3/GT3ST, higher polysialogangliosides including GT3 were detected only in cell lines where the amount of GD3/GT3 mRNA is sufficiently high.
T10 1244-1344 Sentence denotes The expression of GD3/GT3ST mRNA among human tissues is highly restricted to fetal and adult brains.
T10 1244-1344 Sentence denotes The expression of GD3/GT3ST mRNA among human tissues is highly restricted to fetal and adult brains.
T11 1345-1417 Sentence denotes The GD3/GT3ST gene was found to be located at chromosome 12, region p12.
T11 1345-1417 Sentence denotes The GD3/GT3ST gene was found to be located at chromosome 12, region p12.
T12 1418-1618 Sentence denotes Taken together, these results indicate that C series polysialogangliosides are synthesized by a ganglioside-specific polysialyltransferase, GD3/GT3ST, that is specifically expressed in neural tissues.
T12 1418-1618 Sentence denotes Taken together, these results indicate that C series polysialogangliosides are synthesized by a ganglioside-specific polysialyltransferase, GD3/GT3ST, that is specifically expressed in neural tissues.