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PubMed:8631962 JSONTXT 31 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-170 Sentence denotes Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes.
T1 0-170 Sentence denotes Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes.
T2 171-367 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF), supports proliferation, differentiation, and functional activation of hemopoietic cells by its interaction with a heterodimeric receptor.
T2 171-367 Sentence denotes Granulocyte-macrophage colony-stimulating factor (GM-CSF), supports proliferation, differentiation, and functional activation of hemopoietic cells by its interaction with a heterodimeric receptor.
T3 368-621 Sentence denotes Although GM-CSF receptor is devoid of tyrosine kinase enzymatic activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional activation is mediated by the phosphorylation of a large number of intracellular signaling molecules.
T3 368-621 Sentence denotes Although GM-CSF receptor is devoid of tyrosine kinase enzymatic activity, GM-CSF-induced peripheral blood polymorphonuclear leukocytes (PMN) functional activation is mediated by the phosphorylation of a large number of intracellular signaling molecules.
T4 622-718 Sentence denotes We have previously shown that JAK2 becomes tyrosine-phosphorylated in response to GM-CSF in PMN.
T4 622-718 Sentence denotes We have previously shown that JAK2 becomes tyrosine-phosphorylated in response to GM-CSF in PMN.
T5 719-1049 Sentence denotes In the present study we demonstrate that also the signal transducers and activators of transcription (STAT) family members STAT1 p91 and STAT3 p92 and the product of the c-fps/fes protooncogene become tyrosine-phosphorylated upon GM-CSF stimulation and physically associated with both GM-CSF receptor beta common subunit and JAK2.
T5 719-1049 Sentence denotes In the present study we demonstrate that also the signal transducers and activators of transcription (STAT) family members STAT1 p91 and STAT3 p92 and the product of the c-fps/fes protooncogene become tyrosine-phosphorylated upon GM-CSF stimulation and physically associated with both GM-CSF receptor beta common subunit and JAK2.
T6 1050-1120 Sentence denotes Moreover GM-CSF was able to induce JAK2 and p93fes catalytic activity.
T6 1050-1120 Sentence denotes Moreover GM-CSF was able to induce JAK2 and p93fes catalytic activity.
T7 1121-1235 Sentence denotes We also demonstrate that the association of the GM-CSF receptor beta common subunit with JAK2 is ligand-dependent.
T7 1121-1235 Sentence denotes We also demonstrate that the association of the GM-CSF receptor beta common subunit with JAK2 is ligand-dependent.
T8 1236-1332 Sentence denotes Finally we demonstrate that GM-CSF induces a DNA-binding complex that contains both p91 and p92.
T8 1236-1332 Sentence denotes Finally we demonstrate that GM-CSF induces a DNA-binding complex that contains both p91 and p92.
T9 1333-1499 Sentence denotes These results identify a new signal transduction pathway activated by GM-CSF and provide a mechanism for rapid activation of gene expression in GM-CSF-stimulated PMN.
T9 1333-1499 Sentence denotes These results identify a new signal transduction pathway activated by GM-CSF and provide a mechanism for rapid activation of gene expression in GM-CSF-stimulated PMN.