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PubMed:8631821 JSONTXT 32 Projects

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Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
T1 0-120 Sentence denotes Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
T2 121-385 Sentence denotes CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.
T2 121-385 Sentence denotes CD36 is a cell surface glycoprotein composed of a single polypeptide chain, which interacts with thrombospondin, collagens type I and IV, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and erythrocytes parasitized with Plasmodium falciparum.
T3 386-467 Sentence denotes Its expression is restricted to a few cell types, including monocyte/macrophages.
T3 386-467 Sentence denotes Its expression is restricted to a few cell types, including monocyte/macrophages.
T4 468-607 Sentence denotes In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.
T4 468-607 Sentence denotes In these cells, CD36 is involved in phagocytosis of apoptotic cells, and foam cell formation by uptake of oxidized low density lipoprotein.
T5 608-757 Sentence denotes To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.
T5 608-757 Sentence denotes To study the molecular mechanisms that control the transcription of the CD36 gene in monocytic cells we have isolated and analyzed the CD36 promoter.
T6 758-1033 Sentence denotes Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.
T6 758-1033 Sentence denotes Transient expression experiments of 5'-deletion fragments of the CD36 promoter coupled to luciferase demonstrated that as few as 158 base pairs upstream from the transcription initiation site were sufficient to direct the monocyte-specific transcription of the reporter gene.
T7 1034-1163 Sentence denotes Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.
T7 1034-1163 Sentence denotes Within the above region, the fragment spanning nucleotides -158 to -90 was required for optimal transcription in monocytic cells.
T8 1164-1361 Sentence denotes Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.
T8 1164-1361 Sentence denotes Biochemical analysis of the region -158/-90 revealed a binding site for transcription factors of the polyomavirus enhancer-binding protein 2/core-binding factor (PEBP2/CBF) family at position -103.
T9 1362-1500 Sentence denotes Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.
T9 1362-1500 Sentence denotes Disruption of the PEBP2/CBF site markedly diminished the role of the PEBP2/CBF factors in the constitutive transcription of the CD36 gene.
T10 1501-1896 Sentence denotes The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.
T10 1501-1896 Sentence denotes The involvement of members of the PEBP2/CBF family in chromosome translocations associated with acute myeloid leukemia, and in the transcriptional regulation of the myeloid-specific genes encoding for myeloperoxidase, elastase, and the colony-stimulating factor receptor, highlights the relevance of the regulation of the CD36 gene promoter in monocytic cells by members of the PEBP2/CBF family.