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PubMed:8630377 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-125 Sentence denotes Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.
T1 0-125 Sentence denotes Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.
TextSentencer_T2 126-335 Sentence denotes No constant genetic alteration has yet been unravelled in T-cell acute lymphoblastic leukemia (T-ALL), and, to date, the most frequent alteration, the SIL-TAL1 deletion, is found in approximately 20% of cases.
T2 126-335 Sentence denotes No constant genetic alteration has yet been unravelled in T-cell acute lymphoblastic leukemia (T-ALL), and, to date, the most frequent alteration, the SIL-TAL1 deletion, is found in approximately 20% of cases.
TextSentencer_T3 336-513 Sentence denotes Recently, two genes have been identified, the multiple tumor-suppressor gene 1 (MTS1) and multiple tumor-suppressor gene 2 (MTS2), whose products inhibit cell cycle progression.
T3 336-513 Sentence denotes Recently, two genes have been identified, the multiple tumor-suppressor gene 1 (MTS1) and multiple tumor-suppressor gene 2 (MTS2), whose products inhibit cell cycle progression.
TextSentencer_T4 514-637 Sentence denotes A characterization of the MTS locus organization allowed to determine the incidence of MTS1 and MTS2 inactivation in T-ALL.
T4 514-637 Sentence denotes A characterization of the MTS locus organization allowed to determine the incidence of MTS1 and MTS2 inactivation in T-ALL.
TextSentencer_T5 638-773 Sentence denotes MTS1 and MTS2 configurations were determined by Southern blotting using 8 probes in 59 patients with T-ALL (40 children and 19 adults).
T5 638-773 Sentence denotes MTS1 and MTS2 configurations were determined by Southern blotting using 8 probes in 59 patients with T-ALL (40 children and 19 adults).
TextSentencer_T6 774-868 Sentence denotes Biallelic MTS1 inactivation by deletions and/or rearrangements was observed in 45 cases (76%).
T6 774-868 Sentence denotes Biallelic MTS1 inactivation by deletions and/or rearrangements was observed in 45 cases (76%).
TextSentencer_T7 869-921 Sentence denotes Monoallelic alterations were found in 6 cases (10%).
T7 869-921 Sentence denotes Monoallelic alterations were found in 6 cases (10%).
TextSentencer_T8 922-996 Sentence denotes The second MTS1 allele was studied in the 4 cases with available material.
T8 922-996 Sentence denotes The second MTS1 allele was studied in the 4 cases with available material.
TextSentencer_T9 997-1035 Sentence denotes A point mutation was found in 2 cases.
T9 997-1035 Sentence denotes A point mutation was found in 2 cases.
TextSentencer_T10 1036-1124 Sentence denotes The lack of MTS1 mRNA expression was observed by Northern blot analysis in a third case.
T10 1036-1124 Sentence denotes The lack of MTS1 mRNA expression was observed by Northern blot analysis in a third case.
TextSentencer_T11 1125-1359 Sentence denotes A normal single-strand conformation polymorphism pattern of MTS1 exons 1alpha and 2 was found and MTS1 RNA was detected in the fourth case, but a rearrangement occurring 5' to MTS1 exon 1 alpha deleting MTS1 exon 1Beta was documented.
T11 1125-1359 Sentence denotes A normal single-strand conformation polymorphism pattern of MTS1 exons 1alpha and 2 was found and MTS1 RNA was detected in the fourth case, but a rearrangement occurring 5' to MTS1 exon 1 alpha deleting MTS1 exon 1Beta was documented.
TextSentencer_T12 1360-1403 Sentence denotes One case presented a complex rearrangement.
T12 1360-1403 Sentence denotes One case presented a complex rearrangement.
TextSentencer_T13 1404-1471 Sentence denotes Germline configuration for MTS1 and MTS2 was found in only 7 cases.
T13 1404-1471 Sentence denotes Germline configuration for MTS1 and MTS2 was found in only 7 cases.
TextSentencer_T14 1472-1554 Sentence denotes The localization of the 17 breakpoints occurring in the MTS locus were determined.
T14 1472-1554 Sentence denotes The localization of the 17 breakpoints occurring in the MTS locus were determined.
TextSentencer_T15 1555-1668 Sentence denotes Ten of them (59%) are clustered in a 6-kb region located 5 kb downstream to the newly identified MTS1 exon 1Beta.
T15 1555-1668 Sentence denotes Ten of them (59%) are clustered in a 6-kb region located 5 kb downstream to the newly identified MTS1 exon 1Beta.
TextSentencer_T16 1669-1769 Sentence denotes No rearrangement disrupting MTS2 was detected and more rearrangements spared MTS2 than MTS1 (P<.01).
T16 1669-1769 Sentence denotes No rearrangement disrupting MTS2 was detected and more rearrangements spared MTS2 than MTS1 (P<.01).
TextSentencer_T17 1770-1846 Sentence denotes MTS1 but not MTS2 RNA was detected by Northern blotting in the human thymus.
T17 1770-1846 Sentence denotes MTS1 but not MTS2 RNA was detected by Northern blotting in the human thymus.
TextSentencer_T18 1847-1937 Sentence denotes These data strongly suggest that MTS1 is the functional target of rearrangements in T-ALL.
T18 1847-1937 Sentence denotes These data strongly suggest that MTS1 is the functional target of rearrangements in T-ALL.
TextSentencer_T19 1938-2060 Sentence denotes MTS1 inactivation, observed in at least 80% of T-ALL, is the most consistent genetic defect found in this disease to date.
T19 1938-2060 Sentence denotes MTS1 inactivation, observed in at least 80% of T-ALL, is the most consistent genetic defect found in this disease to date.