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PubMed:8626528 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.
T1 0-143 Sentence denotes Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.
T2 144-268 Sentence denotes Activation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28.
T2 144-268 Sentence denotes Activation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28.
T3 269-379 Sentence denotes The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation.
T3 269-379 Sentence denotes The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation.
T4 380-534 Sentence denotes The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals.
T4 380-534 Sentence denotes The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals.
T5 535-612 Sentence denotes The CD28RE sequence reveals similarity to the consensus kappaB binding motif.
T5 535-612 Sentence denotes The CD28RE sequence reveals similarity to the consensus kappaB binding motif.
T6 613-854 Sentence denotes Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members.
T6 613-854 Sentence denotes Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members.
T7 855-1055 Sentence denotes Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling.
T7 855-1055 Sentence denotes Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling.
T8 1056-1130 Sentence denotes Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35.
T8 1056-1130 Sentence denotes Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35.
T9 1131-1262 Sentence denotes These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction.
T9 1131-1262 Sentence denotes These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction.
T10 1263-1356 Sentence denotes Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35.
T10 1263-1356 Sentence denotes Similar to its effect on IL-2 production, cyclosporin A inhibited the induction of NF-MATp35.
T11 1357-1592 Sentence denotes Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression.
T11 1357-1592 Sentence denotes Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression.