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PubMed:8621667 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-137 Sentence denotes The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein.
T1 0-137 Sentence denotes The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein.
T2 138-237 Sentence denotes Common molecular variants of the angiotensinogen gene have been associated with human hypertension.
T2 138-237 Sentence denotes Common molecular variants of the angiotensinogen gene have been associated with human hypertension.
T3 238-337 Sentence denotes The rare Tyr to Cys change at residue 248 of mature angiotensinogen was identified in one pedigree.
T3 238-337 Sentence denotes The rare Tyr to Cys change at residue 248 of mature angiotensinogen was identified in one pedigree.
T4 338-487 Sentence denotes Heterozygous individuals (Y248C) had a 40% decrease in plasma angiotensinogen concentration and a 35% reduction of the angiotensin I production rate.
T4 338-487 Sentence denotes Heterozygous individuals (Y248C) had a 40% decrease in plasma angiotensinogen concentration and a 35% reduction of the angiotensin I production rate.
T5 488-603 Sentence denotes Recombinant wild-type (Tyr-248) and mutant (Cys-248) proteins were stably expressed in Chinese hamster ovary cells.
T5 488-603 Sentence denotes Recombinant wild-type (Tyr-248) and mutant (Cys-248) proteins were stably expressed in Chinese hamster ovary cells.
T6 604-796 Sentence denotes Angiotensinogen monoclonal antibodies revealed marked differences in the epitope recognition of the mutant protein and allowed the demonstration of its presence in plasma of Y248C individuals.
T6 604-796 Sentence denotes Angiotensinogen monoclonal antibodies revealed marked differences in the epitope recognition of the mutant protein and allowed the demonstration of its presence in plasma of Y248C individuals.
T7 797-900 Sentence denotes Similar kinetic constants of angiotensin I production with human renin were observed for both proteins.
T7 797-900 Sentence denotes Similar kinetic constants of angiotensin I production with human renin were observed for both proteins.
T8 901-1061 Sentence denotes Western blot analysis showed similar heterogeneities; however, a 3-kDa increase in molecular mass for the Cys-248 protein was observed after immunopurification.
T8 901-1061 Sentence denotes Western blot analysis showed similar heterogeneities; however, a 3-kDa increase in molecular mass for the Cys-248 protein was observed after immunopurification.
T9 1062-1267 Sentence denotes Metabolic labeling of the intracellular Cys-248 protein showed a 61-kDa band in addition to the 55.5- and 58-kDa bands observed for the Tyr-248 protein, with all bands being sensitive to endoglycosidase H.
T9 1062-1267 Sentence denotes Metabolic labeling of the intracellular Cys-248 protein showed a 61-kDa band in addition to the 55.5- and 58-kDa bands observed for the Tyr-248 protein, with all bands being sensitive to endoglycosidase H.
T10 1268-1368 Sentence denotes In addition, pulse-chase studies revealed a slower intracellular processing for the Cys-248 protein.
T10 1268-1368 Sentence denotes In addition, pulse-chase studies revealed a slower intracellular processing for the Cys-248 protein.
T11 1369-1600 Sentence denotes In conclusion, the Cys-248 mutation alters the structure, glycosylation, and secretion of angiotensinogen in Chinese hamster ovary cells and is accompanied by a decrease in plasma angiotensinogen concentration in Y248C individuals.
T11 1369-1600 Sentence denotes In conclusion, the Cys-248 mutation alters the structure, glycosylation, and secretion of angiotensinogen in Chinese hamster ovary cells and is accompanied by a decrease in plasma angiotensinogen concentration in Y248C individuals.