> top > projects > sentences > docs > PubMed:8621578 > annotations
sentences Home  

PubMed:8621578 JSONTXT 42 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-103 Sentence denotes A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion.
T1 0-103 Sentence denotes A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion.
TextSentencer_T2 104-282 Sentence denotes The seven transmembrane segments (TMs) of many G-protein-coupled receptors (GPCRs) are thought to form a cavity into which cognate ligands insert, leading to receptor activation.
T2 104-282 Sentence denotes The seven transmembrane segments (TMs) of many G-protein-coupled receptors (GPCRs) are thought to form a cavity into which cognate ligands insert, leading to receptor activation.
TextSentencer_T3 283-384 Sentence denotes Residues lining the cavity are often essential for optimal ligand binding and/or signal transduction.
T3 283-384 Sentence denotes Residues lining the cavity are often essential for optimal ligand binding and/or signal transduction.
TextSentencer_T4 385-564 Sentence denotes The present studies evaluated whether residues lining the cavity also contribute to specificity, using GPCRs for the polypeptides parathyroid hormone (PTH) and secretin as models.
T4 385-564 Sentence denotes The present studies evaluated whether residues lining the cavity also contribute to specificity, using GPCRs for the polypeptides parathyroid hormone (PTH) and secretin as models.
TextSentencer_T5 565-684 Sentence denotes These ligands display no sequence homology with one another, and neither ligand cross-reacts with the other's receptor.
T5 565-684 Sentence denotes These ligands display no sequence homology with one another, and neither ligand cross-reacts with the other's receptor.
TextSentencer_T6 685-890 Sentence denotes However, mutation of a single amino acid in the second TM of the secretin receptor to the corresponding residue in the PTH receptor (N192I) resulted in a receptor that binds and signals in response to PTH.
T6 685-890 Sentence denotes However, mutation of a single amino acid in the second TM of the secretin receptor to the corresponding residue in the PTH receptor (N192I) resulted in a receptor that binds and signals in response to PTH.
TextSentencer_T7 891-988 Sentence denotes The reciprocal mutation in the PTH receptor (I234N) likewise unmasked responsiveness to secretin.
T7 891-988 Sentence denotes The reciprocal mutation in the PTH receptor (I234N) likewise unmasked responsiveness to secretin.
TextSentencer_T8 989-1079 Sentence denotes Neither mutation significantly altered the response of the receptors to their own ligands.
T8 989-1079 Sentence denotes Neither mutation significantly altered the response of the receptors to their own ligands.
TextSentencer_T9 1080-1320 Sentence denotes The results suggest a model of specificity wherein TM residues near the extracellular surface of the receptor function as a selectivity filter that restricts access of inappropriate ligands to an activation site in the transmembrane cavity.
T9 1080-1320 Sentence denotes The results suggest a model of specificity wherein TM residues near the extracellular surface of the receptor function as a selectivity filter that restricts access of inappropriate ligands to an activation site in the transmembrane cavity.