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PubMed:8621427 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors.
T1 0-102 Sentence denotes Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors.
T2 103-179 Sentence denotes Generation of receptor-selective VEGF variants by site-directed mutagenesis.
T2 103-179 Sentence denotes Generation of receptor-selective VEGF variants by site-directed mutagenesis.
T3 180-295 Sentence denotes Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli.
T3 180-295 Sentence denotes Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli.
T4 296-521 Sentence denotes VEGF mediates endothelial cell proliferation, angiogenesis, vascular growth, and vascular permeability via the endothelial cell receptors, kinase insert domain-containing receptor (KDR)/fetal liver kinase 1 (Flk-1) and FLT-1.
T4 296-521 Sentence denotes VEGF mediates endothelial cell proliferation, angiogenesis, vascular growth, and vascular permeability via the endothelial cell receptors, kinase insert domain-containing receptor (KDR)/fetal liver kinase 1 (Flk-1) and FLT-1.
T5 522-644 Sentence denotes Alanine-scanning mutagenesis was used to identify a positively charged surface in VEGF that mediates binding to KDR/Flk-1.
T5 522-644 Sentence denotes Alanine-scanning mutagenesis was used to identify a positively charged surface in VEGF that mediates binding to KDR/Flk-1.
T6 645-840 Sentence denotes Arg82, Lys84 and His86, located in a hairpin loop, were found to be critical for binding KDR/Flk-1, while negatively charged residues, Asp63, Glu64, and Glu67, were associated with FLT-1 binding.
T6 645-840 Sentence denotes Arg82, Lys84 and His86, located in a hairpin loop, were found to be critical for binding KDR/Flk-1, while negatively charged residues, Asp63, Glu64, and Glu67, were associated with FLT-1 binding.
T7 841-990 Sentence denotes A VEGF model based on PDGFb indicated these positively and negatively charged regions are distal in the monomer but are spatially close in the dimer.
T7 841-990 Sentence denotes A VEGF model based on PDGFb indicated these positively and negatively charged regions are distal in the monomer but are spatially close in the dimer.
T8 991-1124 Sentence denotes Mutations within the KDR site had minimal effect on FLT-1 binding, and mutants deficient in FLT-1 binding did not affect KDR binding.
T8 991-1124 Sentence denotes Mutations within the KDR site had minimal effect on FLT-1 binding, and mutants deficient in FLT-1 binding did not affect KDR binding.
T9 1125-1263 Sentence denotes Endothelial cell mitogenesis was abolished in mutants lacking KDR affinity; however, FLT-1 deficient mutants induced normal proliferation.
T9 1125-1263 Sentence denotes Endothelial cell mitogenesis was abolished in mutants lacking KDR affinity; however, FLT-1 deficient mutants induced normal proliferation.
T10 1264-1422 Sentence denotes These results suggest dual sets of determinants in the VEGF dimer that cross-link cell surface receptors, triggering endothelial cell growth and angiogenesis.
T10 1264-1422 Sentence denotes These results suggest dual sets of determinants in the VEGF dimer that cross-link cell surface receptors, triggering endothelial cell growth and angiogenesis.
T11 1423-1544 Sentence denotes Furthermore, this mutational analysis implicates KDR, but not FLT-1, in VEGF induction of endothelial cell proliferation.
T11 1423-1544 Sentence denotes Furthermore, this mutational analysis implicates KDR, but not FLT-1, in VEGF induction of endothelial cell proliferation.