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PubMed:8576111 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
T1 0-109 Sentence denotes Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
T2 110-283 Sentence denotes In T lymphocytes, the calcium/calmodulin-dependent serine/threonine phosphatase, calcineurin, plays a pivotal role in transducing membrane-associated signals to the nucleus.
T2 110-283 Sentence denotes In T lymphocytes, the calcium/calmodulin-dependent serine/threonine phosphatase, calcineurin, plays a pivotal role in transducing membrane-associated signals to the nucleus.
T3 284-538 Sentence denotes One of the putative targets of calcineurin is the pre-existing, cytosolic component of the nuclear factor of activated T cells (NFATp; also referred to as NFAT1), which is one of several transcription factors required for the expression of interleukin 2.
T3 284-538 Sentence denotes One of the putative targets of calcineurin is the pre-existing, cytosolic component of the nuclear factor of activated T cells (NFATp; also referred to as NFAT1), which is one of several transcription factors required for the expression of interleukin 2.
T4 539-693 Sentence denotes Inhibition of calcineurin by the immunosuppressive drugs cyclosporin A and FK506 prevents dephosphorylation of NFATp and its translocation to the nucleus.
T4 539-693 Sentence denotes Inhibition of calcineurin by the immunosuppressive drugs cyclosporin A and FK506 prevents dephosphorylation of NFATp and its translocation to the nucleus.
T5 694-782 Sentence denotes However, a physical interaction between calcineurin and NFATp has not been demonstrated.
T5 694-782 Sentence denotes However, a physical interaction between calcineurin and NFATp has not been demonstrated.
T6 783-875 Sentence denotes Here we demonstrate the binding of NFATp from lysates of T cells to immobilized calcineurin.
T6 783-875 Sentence denotes Here we demonstrate the binding of NFATp from lysates of T cells to immobilized calcineurin.
T7 876-1008 Sentence denotes Stimulation of T cells with calcium ionophore induced a shift in the molecular weight of NFATp that is due to its dephosphorylation.
T7 876-1008 Sentence denotes Stimulation of T cells with calcium ionophore induced a shift in the molecular weight of NFATp that is due to its dephosphorylation.
T8 1009-1119 Sentence denotes This dephosphorylation was inhibited by treatment of T cells with cyclosporin A or FK506 prior to stimulation.
T8 1009-1119 Sentence denotes This dephosphorylation was inhibited by treatment of T cells with cyclosporin A or FK506 prior to stimulation.
T9 1120-1213 Sentence denotes Of note, both the phosphorylated and the dephosphorylated form of NFATp bound to calcineurin.
T9 1120-1213 Sentence denotes Of note, both the phosphorylated and the dephosphorylated form of NFATp bound to calcineurin.
T10 1214-1368 Sentence denotes Furthermore, the binding of both forms of NFATp to calcineurin was inhibited by pretreatment of calcineurin with a complex of FK506 and its ligand FKBP12.
T10 1214-1368 Sentence denotes Furthermore, the binding of both forms of NFATp to calcineurin was inhibited by pretreatment of calcineurin with a complex of FK506 and its ligand FKBP12.
T11 1369-1564 Sentence denotes Taken together these data strongly suggest a direct interaction of calcineurin with NFATp and that this interaction does not depend upon the phosphorylation sites of NFATp affected by activation.
T11 1369-1564 Sentence denotes Taken together these data strongly suggest a direct interaction of calcineurin with NFATp and that this interaction does not depend upon the phosphorylation sites of NFATp affected by activation.