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PubMed:8554067 JSONTXT 15 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-73 Sentence denotes A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.
T1 0-73 Sentence denotes A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.
TextSentencer_T2 74-244 Sentence denotes We have analyzed 20 breast-ovarian cancer families, the majority of which show positive evidence of linkage to chromosome 17q12 for germ-line mutations in the BRCA1 gene.
T2 74-244 Sentence denotes We have analyzed 20 breast-ovarian cancer families, the majority of which show positive evidence of linkage to chromosome 17q12 for germ-line mutations in the BRCA1 gene.
TextSentencer_T3 245-406 Sentence denotes BRCA1 mutations cosegregating with breast and ovarian cancer susceptibility were identified in 16 families, including 1 family with a case of male breast cancer.
T3 245-406 Sentence denotes BRCA1 mutations cosegregating with breast and ovarian cancer susceptibility were identified in 16 families, including 1 family with a case of male breast cancer.
TextSentencer_T4 407-465 Sentence denotes Nine of these mutations have not been reported previously.
T4 407-465 Sentence denotes Nine of these mutations have not been reported previously.
TextSentencer_T5 466-632 Sentence denotes The majority of mutations were found to generate a premature stop codon leading to the formation of a truncated BRCA1 protein of 2%-88% of the expected normal length.
T5 466-632 Sentence denotes The majority of mutations were found to generate a premature stop codon leading to the formation of a truncated BRCA1 protein of 2%-88% of the expected normal length.
TextSentencer_T6 633-678 Sentence denotes Two mutations altered the RING finger domain.
T6 633-678 Sentence denotes Two mutations altered the RING finger domain.
TextSentencer_T7 679-891 Sentence denotes Sequencing of genomic DNA led to the identification of a mutation in the coding region of BRCA1 in 12 families, and cDNA analysis revealed an abnormal or missing BRCA1 transcript in 4 of the 8 remaining families.
T7 679-891 Sentence denotes Sequencing of genomic DNA led to the identification of a mutation in the coding region of BRCA1 in 12 families, and cDNA analysis revealed an abnormal or missing BRCA1 transcript in 4 of the 8 remaining families.
TextSentencer_T8 892-979 Sentence denotes A total of eight mutations were associated with a reduced quantity of BRCA1 transcript.
T8 892-979 Sentence denotes A total of eight mutations were associated with a reduced quantity of BRCA1 transcript.
TextSentencer_T9 980-1094 Sentence denotes We were unable to detect BRCA1 mutations in 4 of the 20 families, but only 1 of these was clearly linked to BRCA1.
T9 980-1094 Sentence denotes We were unable to detect BRCA1 mutations in 4 of the 20 families, but only 1 of these was clearly linked to BRCA1.
TextSentencer_T10 1095-1251 Sentence denotes It is expected that the majority of clear examples of the breast-ovarian syndrome will be associated with germ-line mutations in the coding region of BRCA1.
T10 1095-1251 Sentence denotes It is expected that the majority of clear examples of the breast-ovarian syndrome will be associated with germ-line mutations in the coding region of BRCA1.