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PubMed:8550604 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Biochemical characterization of the human cyclin-dependent protein kinase activating kinase.
T1 0-92 Sentence denotes Biochemical characterization of the human cyclin-dependent protein kinase activating kinase.
T2 93-145 Sentence denotes Identification of p35 as a novel regulatory subunit.
T2 93-145 Sentence denotes Identification of p35 as a novel regulatory subunit.
T3 146-338 Sentence denotes The activation of cyclin-dependent protein kinases (Cdks) is dependent upon site-specific phosphorylation and dephosphorylation reactions, as well as positive and negative regulatory subunits.
T3 146-338 Sentence denotes The activation of cyclin-dependent protein kinases (Cdks) is dependent upon site-specific phosphorylation and dephosphorylation reactions, as well as positive and negative regulatory subunits.
T4 339-473 Sentence denotes The human Cdk-activating protein kinase (Cak1) is itself a Cdc2-related cyclin-dependent protein kinase that associates with cyclin H.
T4 339-473 Sentence denotes The human Cdk-activating protein kinase (Cak1) is itself a Cdc2-related cyclin-dependent protein kinase that associates with cyclin H.
T5 474-645 Sentence denotes The present study utilized specific anti-Cak1 antibodies and immunoaffinity chromatography to identify additional Cak1-associated proteins and potential target substrates.
T5 474-645 Sentence denotes The present study utilized specific anti-Cak1 antibodies and immunoaffinity chromatography to identify additional Cak1-associated proteins and potential target substrates.
T6 646-853 Sentence denotes Immunoprecipitation of metabolically labeled human osteosarcoma cells revealed a number of Cak1-associated proteins, including p95, p37 (cyclin H), and a 35-kDa protein that was further characterized herein.
T6 646-853 Sentence denotes Immunoprecipitation of metabolically labeled human osteosarcoma cells revealed a number of Cak1-associated proteins, including p95, p37 (cyclin H), and a 35-kDa protein that was further characterized herein.
T7 854-1061 Sentence denotes Microsequence analysis obtained after limited proteolysis revealed peptide fragments that are similar, but not identical to, human and yeast cyclins, thus identifying p35 as a cyclin-like regulatory subunit.
T7 854-1061 Sentence denotes Microsequence analysis obtained after limited proteolysis revealed peptide fragments that are similar, but not identical to, human and yeast cyclins, thus identifying p35 as a cyclin-like regulatory subunit.
T8 1062-1182 Sentence denotes The greatest sequence similarity of human p35 is with Mcs2, a yeast cyclin that is essential for cell cycle progression.
T8 1062-1182 Sentence denotes The greatest sequence similarity of human p35 is with Mcs2, a yeast cyclin that is essential for cell cycle progression.
T9 1183-1410 Sentence denotes Immunoaffinity chromatography performed under nondenaturing conditions afforded the isolation of enzymatically active Cak1 from cell lysates, enabling studies of kinase autophosphorylation and comparative substrate utilization.
T9 1183-1410 Sentence denotes Immunoaffinity chromatography performed under nondenaturing conditions afforded the isolation of enzymatically active Cak1 from cell lysates, enabling studies of kinase autophosphorylation and comparative substrate utilization.
T10 1411-1591 Sentence denotes Immunoaffinity-purified Cak1 phosphorylated monomeric Cdc2 and Cdk2, but not Cdk4; the phosphorylation of both Cdc2 and Cdk2 were increased in the presence of recombinant cyclin A.
T10 1411-1591 Sentence denotes Immunoaffinity-purified Cak1 phosphorylated monomeric Cdc2 and Cdk2, but not Cdk4; the phosphorylation of both Cdc2 and Cdk2 were increased in the presence of recombinant cyclin A.
T11 1592-1814 Sentence denotes These studies indicate that the Cak1 catalytic subunit, like Cdc2 and Cdk2, associates with multiple regulatory partners and suggests that subunit composition may be an important determinant of this multifunctional enzyme.
T11 1592-1814 Sentence denotes These studies indicate that the Cak1 catalytic subunit, like Cdc2 and Cdk2, associates with multiple regulatory partners and suggests that subunit composition may be an important determinant of this multifunctional enzyme.