> top > projects > sentences > docs > PubMed:8548755 > annotations
sentences Home  

PubMed:8548755 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-96 Sentence denotes CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.
T1 0-96 Sentence denotes CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.
TextSentencer_T2 97-232 Sentence denotes p16 is involved in a cell cycle regulatory cascade that includes cyclin-dependent kinase 4 (cdk4), cyclin D1, and pRb (retinoblastoma).
T2 97-232 Sentence denotes p16 is involved in a cell cycle regulatory cascade that includes cyclin-dependent kinase 4 (cdk4), cyclin D1, and pRb (retinoblastoma).
TextSentencer_T3 233-361 Sentence denotes Alterations of each of these components have been described in primary human glioblastoma multiforme (GBM) or in GBM cell lines.
T3 233-361 Sentence denotes Alterations of each of these components have been described in primary human glioblastoma multiforme (GBM) or in GBM cell lines.
TextSentencer_T4 362-655 Sentence denotes Because perturbation of any component in this pathway may have similar oncogenic effects, we studied the relationship between abnormalities of CDKN2/p16 and RB, the two commonly involved tumor suppressor genes, in 55 astrocytic gliomas (42 GBMs, 8 anaplastic astrocytomas, and 5 astrocytomas).
T4 362-655 Sentence denotes Because perturbation of any component in this pathway may have similar oncogenic effects, we studied the relationship between abnormalities of CDKN2/p16 and RB, the two commonly involved tumor suppressor genes, in 55 astrocytic gliomas (42 GBMs, 8 anaplastic astrocytomas, and 5 astrocytomas).
TextSentencer_T5 656-799 Sentence denotes By using comparative multiplex PCR, homozygous deletions of the CDKN2/p16 gene were detected in 24 GBMs (57%) and in 2 anaplastic astrocytomas.
T5 656-799 Sentence denotes By using comparative multiplex PCR, homozygous deletions of the CDKN2/p16 gene were detected in 24 GBMs (57%) and in 2 anaplastic astrocytomas.
TextSentencer_T6 800-960 Sentence denotes Two additional GBMs and one anaplastic astrocytoma had allelic loss of chromosome 9p, as assessed by microsatellite polymorphisms flanking the CDKN2/p16 region.
T6 800-960 Sentence denotes Two additional GBMs and one anaplastic astrocytoma had allelic loss of chromosome 9p, as assessed by microsatellite polymorphisms flanking the CDKN2/p16 region.
TextSentencer_T7 961-1181 Sentence denotes Single-strand conformation polymorphism and DNA sequencing analysis of all three coding exons of CDKN2/p16 revealed a frameshift mutation (four-bp deletion) in one of the three GBMs that had lost the remaining 9p allele.
T7 961-1181 Sentence denotes Single-strand conformation polymorphism and DNA sequencing analysis of all three coding exons of CDKN2/p16 revealed a frameshift mutation (four-bp deletion) in one of the three GBMs that had lost the remaining 9p allele.
TextSentencer_T8 1182-1331 Sentence denotes Allelic loss of chromosome 13q at the RB gene, RB gene mutations, or loss of pRb expression was noted in 14 GBMs (33%) and 2 anaplastic astrocytomas.
T8 1182-1331 Sentence denotes Allelic loss of chromosome 13q at the RB gene, RB gene mutations, or loss of pRb expression was noted in 14 GBMs (33%) and 2 anaplastic astrocytomas.
TextSentencer_T9 1332-1510 Sentence denotes Thirty-six of 42 GBMs (86%) had alterations of either CDKN2/p16 (n = 22), RB (n = 10), or both (n = 4); these two genetic changes, however, were relatively exclusive (P = 0.003).
T9 1332-1510 Sentence denotes Thirty-six of 42 GBMs (86%) had alterations of either CDKN2/p16 (n = 22), RB (n = 10), or both (n = 4); these two genetic changes, however, were relatively exclusive (P = 0.003).
TextSentencer_T10 1511-1628 Sentence denotes Furthermore, of the six GBMs without either CDKN2/p16 or RB gene abnormalities, one case had CDK4 gene amplification.
T10 1511-1628 Sentence denotes Furthermore, of the six GBMs without either CDKN2/p16 or RB gene abnormalities, one case had CDK4 gene amplification.
TextSentencer_T11 1629-1745 Sentence denotes These data indicate that the vast majority of GBMs probably have inactivation of the p16-cdk4/cyclin D1-pRb pathway.
T11 1629-1745 Sentence denotes These data indicate that the vast majority of GBMs probably have inactivation of the p16-cdk4/cyclin D1-pRb pathway.
TextSentencer_T12 1746-1904 Sentence denotes The findings also provide corroborative evidence that CDKN2/p16 and RB are the critical glioma tumor suppressor genes on chromosomes 9p and 13q, respectively.
T12 1746-1904 Sentence denotes The findings also provide corroborative evidence that CDKN2/p16 and RB are the critical glioma tumor suppressor genes on chromosomes 9p and 13q, respectively.