| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-138 |
Sentence |
denotes |
Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells. |
| T1 |
0-138 |
Sentence |
denotes |
Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells. |
| T2 |
139-332 |
Sentence |
denotes |
Many effects of lipopolysaccharide (LPS) on gene expression, including that of human immunodeficiency virus (HIV), in monocytic cells are mediated by activation of kappa B DNA-binding proteins. |
| T2 |
139-332 |
Sentence |
denotes |
Many effects of lipopolysaccharide (LPS) on gene expression, including that of human immunodeficiency virus (HIV), in monocytic cells are mediated by activation of kappa B DNA-binding proteins. |
| T3 |
333-528 |
Sentence |
denotes |
However, the specific members of the NF-kappa B/Rel transcription factor family involved in the LPS response, and the mechanisms through which LPS-generated signals are transduced remain unclear. |
| T3 |
333-528 |
Sentence |
denotes |
However, the specific members of the NF-kappa B/Rel transcription factor family involved in the LPS response, and the mechanisms through which LPS-generated signals are transduced remain unclear. |
| T4 |
529-697 |
Sentence |
denotes |
Here we show that LPS induces nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells. |
| T4 |
529-697 |
Sentence |
denotes |
Here we show that LPS induces nuclear expression of c-Rel/p50 heterodimers as well as p50/p65 (NF-kappa B) kappa B DNA-binding complexes in human monocytic THP-1 cells. |
| T5 |
698-872 |
Sentence |
denotes |
Nuclear localization of these proteins occurred concomitantly with a rapid decrease in their cytosolic levels and was independent of phorbol ester-sensitive protein kinase C. |
| T5 |
698-872 |
Sentence |
denotes |
Nuclear localization of these proteins occurred concomitantly with a rapid decrease in their cytosolic levels and was independent of phorbol ester-sensitive protein kinase C. |
| T6 |
873-994 |
Sentence |
denotes |
Within 24 h following LPS stimulation there was a striking increase in the levels of c-Rel, p105, and p50 in the cytosol. |
| T6 |
873-994 |
Sentence |
denotes |
Within 24 h following LPS stimulation there was a striking increase in the levels of c-Rel, p105, and p50 in the cytosol. |
| T7 |
995-1127 |
Sentence |
denotes |
The increased levels of these proteins correlated with increases in the amounts of their mRNAs during LPS activation of THP-1 cells. |
| T7 |
995-1127 |
Sentence |
denotes |
The increased levels of these proteins correlated with increases in the amounts of their mRNAs during LPS activation of THP-1 cells. |
| T8 |
1128-1293 |
Sentence |
denotes |
LPS activation of THP-1 cells resulted in phosphorylation of MAD3 (an I kappa B-like protein), a rapid increase in MAD3 mRNA, and an increase in MAD3 protein by 2 h. |
| T8 |
1128-1293 |
Sentence |
denotes |
LPS activation of THP-1 cells resulted in phosphorylation of MAD3 (an I kappa B-like protein), a rapid increase in MAD3 mRNA, and an increase in MAD3 protein by 2 h. |
| T9 |
1294-1444 |
Sentence |
denotes |
Thus, LPS activation of human monocytic cells results in nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B) and induces phosphorylation of MAD3. |
| T9 |
1294-1444 |
Sentence |
denotes |
Thus, LPS activation of human monocytic cells results in nuclear expression of c-Rel/p50 and p50/p65 (NF-kappa B) and induces phosphorylation of MAD3. |