> top > projects > sentences > docs > PubMed:8486665 > annotations
sentences Home  

PubMed:8486665 JSONTXT 38 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-64 Sentence denotes Deficient expression of decorin in infantile progeroid patients.
T1 0-64 Sentence denotes Deficient expression of decorin in infantile progeroid patients.
T2 65-215 Sentence denotes Fibroblasts from young patients exhibiting clinical features of progeroidal syndromes showed decreased biosynthesis of the small proteoglycan decorin.
T2 65-215 Sentence denotes Fibroblasts from young patients exhibiting clinical features of progeroidal syndromes showed decreased biosynthesis of the small proteoglycan decorin.
T3 216-416 Sentence denotes Cells in culture were metabolically labeled, and proteoglycans secreted into the medium were analyzed electrophoretically after immunoprecipitation with antibodies raised against decorin and biglycan.
T3 216-416 Sentence denotes Cells in culture were metabolically labeled, and proteoglycans secreted into the medium were analyzed electrophoretically after immunoprecipitation with antibodies raised against decorin and biglycan.
T4 417-566 Sentence denotes Fluorograms showed regularly a reduction to 15-30% of the normal amount of mature decorin and its core protein after chondroitin ABC lyase treatment.
T4 417-566 Sentence denotes Fluorograms showed regularly a reduction to 15-30% of the normal amount of mature decorin and its core protein after chondroitin ABC lyase treatment.
T5 567-709 Sentence denotes The size of the glycosaminoglycan chains was increased, but there was no obvious anomaly in the secretion kinetics of the mature proteoglycan.
T5 567-709 Sentence denotes The size of the glycosaminoglycan chains was increased, but there was no obvious anomaly in the secretion kinetics of the mature proteoglycan.
T6 710-839 Sentence denotes In addition, the patients' fibroblasts synthesized an increased amount of biglycan compared to control cells from healthy donors.
T6 710-839 Sentence denotes In addition, the patients' fibroblasts synthesized an increased amount of biglycan compared to control cells from healthy donors.
T7 840-1061 Sentence denotes Northern blot analysis clearly demonstrated a reduction by 85-94% in decorin mRNA, but biglycan mRNA was concomitantly increased, indicating that these alterations occur at the transcriptional level of protein expression.
T7 840-1061 Sentence denotes Northern blot analysis clearly demonstrated a reduction by 85-94% in decorin mRNA, but biglycan mRNA was concomitantly increased, indicating that these alterations occur at the transcriptional level of protein expression.
T8 1062-1192 Sentence denotes Transcription of decorin in fibroblasts from one of the patients was stimulated up to 3-fold by treatment with interleukin-1 beta.
T8 1062-1192 Sentence denotes Transcription of decorin in fibroblasts from one of the patients was stimulated up to 3-fold by treatment with interleukin-1 beta.
T9 1193-1310 Sentence denotes No response to interleukin-1 beta and transforming growth factor-beta was observed in the cells from another patient.
T9 1193-1310 Sentence denotes No response to interleukin-1 beta and transforming growth factor-beta was observed in the cells from another patient.
T10 1311-1454 Sentence denotes In situ hybridization of cultured cells with an antisense decorin probe showed that decorin levels were reduced throughout the cell population.
T10 1311-1454 Sentence denotes In situ hybridization of cultured cells with an antisense decorin probe showed that decorin levels were reduced throughout the cell population.
T11 1455-1637 Sentence denotes Surprisingly, subsequent examination of cells from one of the patients, now in mid-teenage, revealed a return to normal levels of decorin expression compared to age-matched controls.
T11 1455-1637 Sentence denotes Surprisingly, subsequent examination of cells from one of the patients, now in mid-teenage, revealed a return to normal levels of decorin expression compared to age-matched controls.
T12 1638-1862 Sentence denotes These studies suggest that, as in Marfan's syndrome where the primary defect concerns the fibrillin gene, reduced decorin expression contributes to the formation of an abnormal matrix and the pathogenesis of these disorders.
T12 1638-1862 Sentence denotes These studies suggest that, as in Marfan's syndrome where the primary defect concerns the fibrillin gene, reduced decorin expression contributes to the formation of an abnormal matrix and the pathogenesis of these disorders.
T13 1863-2021 Sentence denotes They also indicate that this abnormality is likely to represent a secondary phenomenon which leads to a fault in the regulation of decorin gene transcription.
T13 1863-2021 Sentence denotes They also indicate that this abnormality is likely to represent a secondary phenomenon which leads to a fault in the regulation of decorin gene transcription.