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PubMed:8449904 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Transcriptional regulation of the pyruvate kinase erythroid-specific promoter.
T1 0-78 Sentence denotes Transcriptional regulation of the pyruvate kinase erythroid-specific promoter.
T2 79-128 Sentence denotes Mammal pyruvate kinases are encoded by two genes.
T2 79-128 Sentence denotes Mammal pyruvate kinases are encoded by two genes.
T3 129-241 Sentence denotes The L gene produces the erythroid (R-PK) or the hepatic (L-PK) isozymes by the alternative use of two promoters.
T3 129-241 Sentence denotes The L gene produces the erythroid (R-PK) or the hepatic (L-PK) isozymes by the alternative use of two promoters.
T4 242-385 Sentence denotes We report the characterization of the cis- and trans-acting elements involved in the tissue-specific activity of the L gene erythroid promoter.
T4 242-385 Sentence denotes We report the characterization of the cis- and trans-acting elements involved in the tissue-specific activity of the L gene erythroid promoter.
T5 386-507 Sentence denotes A R-PK DNA fragment extending from -870 to +54 relative to the cap site confers erythroid specificity to a reporter gene.
T5 386-507 Sentence denotes A R-PK DNA fragment extending from -870 to +54 relative to the cap site confers erythroid specificity to a reporter gene.
T6 508-647 Sentence denotes Within this region, we define a minimal promoter (-62 to +54) that displays erythroid-specific activity and contains two DNA binding sites.
T6 508-647 Sentence denotes Within this region, we define a minimal promoter (-62 to +54) that displays erythroid-specific activity and contains two DNA binding sites.
T7 648-772 Sentence denotes One, located at -50, binds members of the CCACC/Sp1 family and the other, located at -20, binds the erythroid factor GATA-1.
T7 648-772 Sentence denotes One, located at -50, binds members of the CCACC/Sp1 family and the other, located at -20, binds the erythroid factor GATA-1.
T8 773-880 Sentence denotes Although the -20 GATA binding site (AGATAA) is also a potential TFIID binding site, it does not bind TFIID.
T8 773-880 Sentence denotes Although the -20 GATA binding site (AGATAA) is also a potential TFIID binding site, it does not bind TFIID.
T9 881-1004 Sentence denotes Furthermore, the substitution of this GATA binding site by a canonical TFIID binding site suppresses the promoter activity.
T9 881-1004 Sentence denotes Furthermore, the substitution of this GATA binding site by a canonical TFIID binding site suppresses the promoter activity.
T10 1005-1195 Sentence denotes Mutations and deletions of both sites indicate that only the association of CCACC/Sp1 and GATA binding sites can drive efficient and tissue-specific expression of this R-PK minimal promoter.
T10 1005-1195 Sentence denotes Mutations and deletions of both sites indicate that only the association of CCACC/Sp1 and GATA binding sites can drive efficient and tissue-specific expression of this R-PK minimal promoter.
T11 1196-1334 Sentence denotes Finally, by co-transfection experiments, we study the elements involved in the hGATA-1 transactivation of the R-PK promoter in HeLa cells.
T11 1196-1334 Sentence denotes Finally, by co-transfection experiments, we study the elements involved in the hGATA-1 transactivation of the R-PK promoter in HeLa cells.