| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-230 |
Sentence |
denotes |
Suppression of a cellular differentiation program by phorbol esters coincides with inhibition of binding of a cell-specific transcription factor (NF-E2) to an enhancer element required for expression of an erythroid-specific gene. |
| T1 |
0-230 |
Sentence |
denotes |
Suppression of a cellular differentiation program by phorbol esters coincides with inhibition of binding of a cell-specific transcription factor (NF-E2) to an enhancer element required for expression of an erythroid-specific gene. |
| T2 |
231-399 |
Sentence |
denotes |
Induction by hemin increases, while induction with 12-O-tetradecanoylphorbol-13-acetate (TPA) represses, erythroid-specific gene expression in the human cell line K562. |
| T2 |
231-399 |
Sentence |
denotes |
Induction by hemin increases, while induction with 12-O-tetradecanoylphorbol-13-acetate (TPA) represses, erythroid-specific gene expression in the human cell line K562. |
| T3 |
400-614 |
Sentence |
denotes |
We analyzed the effects of hemin or TPA induction on the binding and activity of transcription factors at a regulatory element found within the transcriptional regulatory sequences of many erythroid-specific genes. |
| T3 |
400-614 |
Sentence |
denotes |
We analyzed the effects of hemin or TPA induction on the binding and activity of transcription factors at a regulatory element found within the transcriptional regulatory sequences of many erythroid-specific genes. |
| T4 |
615-694 |
Sentence |
denotes |
TPA induction increases the binding of ubiquitous AP-1 factors to this element. |
| T4 |
615-694 |
Sentence |
denotes |
TPA induction increases the binding of ubiquitous AP-1 factors to this element. |
| T5 |
695-820 |
Sentence |
denotes |
TPA induction inhibits the binding of the lineage limited transcription factor NF-E2 to this transcriptional control element. |
| T5 |
695-820 |
Sentence |
denotes |
TPA induction inhibits the binding of the lineage limited transcription factor NF-E2 to this transcriptional control element. |
| T6 |
821-916 |
Sentence |
denotes |
Hemin induction of K562 cells does not facilitate the binding of NF-E2 to its recognition site. |
| T6 |
821-916 |
Sentence |
denotes |
Hemin induction of K562 cells does not facilitate the binding of NF-E2 to its recognition site. |
| T7 |
917-1031 |
Sentence |
denotes |
Hemin induction appears to nonspecifically increase the expression of transiently transfected genes in K562 cells. |
| T7 |
917-1031 |
Sentence |
denotes |
Hemin induction appears to nonspecifically increase the expression of transiently transfected genes in K562 cells. |
| T8 |
1032-1181 |
Sentence |
denotes |
Beyond this nonspecific increase in gene expression, hemin induction acts to increase the activity of the lineage limited transcription factor NF-E2. |
| T8 |
1032-1181 |
Sentence |
denotes |
Beyond this nonspecific increase in gene expression, hemin induction acts to increase the activity of the lineage limited transcription factor NF-E2. |
| T9 |
1182-1340 |
Sentence |
denotes |
The divergent effects of hemin and TPA on gene expression in K562 cells are mediated, in part, by their contrasting effects on the transcription factor NF-E2. |
| T9 |
1182-1340 |
Sentence |
denotes |
The divergent effects of hemin and TPA on gene expression in K562 cells are mediated, in part, by their contrasting effects on the transcription factor NF-E2. |