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PubMed:8444876 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.
T1 0-115 Sentence denotes A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene.
T2 116-230 Sentence denotes The expression of thrombospondin 1 (TSP 1), a member of the TSP gene family, is rapidly induced by growth factors.
T2 116-230 Sentence denotes The expression of thrombospondin 1 (TSP 1), a member of the TSP gene family, is rapidly induced by growth factors.
T3 231-369 Sentence denotes We tested the ability of human TSP 1-chloramphenicol acetyltransferase constructs to respond to serum in stably transfected NIH-3T3 cells.
T3 231-369 Sentence denotes We tested the ability of human TSP 1-chloramphenicol acetyltransferase constructs to respond to serum in stably transfected NIH-3T3 cells.
T4 370-543 Sentence denotes Two transcriptional elements in the TSP 1 promoter, a distal element at -1280 and a proximal element at -65, were required for the response of the human TSP 1 gene to serum.
T4 370-543 Sentence denotes Two transcriptional elements in the TSP 1 promoter, a distal element at -1280 and a proximal element at -65, were required for the response of the human TSP 1 gene to serum.
T5 544-663 Sentence denotes The distal element contains the 5'-CC(A + T)6GG-3' consensus sequence characteristic of a serum-response element (SRE).
T5 544-663 Sentence denotes The distal element contains the 5'-CC(A + T)6GG-3' consensus sequence characteristic of a serum-response element (SRE).
T6 664-758 Sentence denotes Deletions or mutations in this element reduced the serum response of the TSP 1 gene by 80-90%.
T6 664-758 Sentence denotes Deletions or mutations in this element reduced the serum response of the TSP 1 gene by 80-90%.
T7 759-885 Sentence denotes In gel-shift assays, the -1280 element and the c-fos SRE cross-competed, whereas their functional and binding mutants did not.
T7 759-885 Sentence denotes In gel-shift assays, the -1280 element and the c-fos SRE cross-competed, whereas their functional and binding mutants did not.
T8 886-1055 Sentence denotes The proximal element contains the sequence 5'-GGCCAATGGG-3', which closely resembles the consensus binding motif for the CCAAT-binding factor NF-Y (CBF, CP1, alpha CP1).
T8 886-1055 Sentence denotes The proximal element contains the sequence 5'-GGCCAATGGG-3', which closely resembles the consensus binding motif for the CCAAT-binding factor NF-Y (CBF, CP1, alpha CP1).
T9 1056-1137 Sentence denotes Deletions or mutations in this element also reduced the serum response by 80-90%.
T9 1056-1137 Sentence denotes Deletions or mutations in this element also reduced the serum response by 80-90%.
T10 1138-1400 Sentence denotes Methylation interference analysis of the -65 region identified a pattern of contacts with nuclear factors resembling that for NF-Y, and an NF-Y-binding site and the proximal TSP 1 element cross-competed in gel-shift assays, whereas their binding mutants did not.
T10 1138-1400 Sentence denotes Methylation interference analysis of the -65 region identified a pattern of contacts with nuclear factors resembling that for NF-Y, and an NF-Y-binding site and the proximal TSP 1 element cross-competed in gel-shift assays, whereas their binding mutants did not.
T11 1401-1579 Sentence denotes Finally, an abbreviated TSP 1 promoter/5'-flank, containing the SRE- and NF-Y-binding sites, mediated a serum response that was close in magnitude to that of the parent promoter.
T11 1401-1579 Sentence denotes Finally, an abbreviated TSP 1 promoter/5'-flank, containing the SRE- and NF-Y-binding sites, mediated a serum response that was close in magnitude to that of the parent promoter.
T12 1580-1707 Sentence denotes We conclude that the serum response of the human TSP 1 gene requires the coordinated function of an SRE- and NF-Y-binding site.
T12 1580-1707 Sentence denotes We conclude that the serum response of the human TSP 1 gene requires the coordinated function of an SRE- and NF-Y-binding site.