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PubMed:8428966 JSONTXT 29 Projects

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Id Subject Object Predicate Lexical cue
T1 0-136 Sentence denotes Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.
T1 0-136 Sentence denotes Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.
T2 137-418 Sentence denotes The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor.
T2 137-418 Sentence denotes The lymphoid-specific transcription complex, NF-AT, is involved in early gene activation in T cells and is assembled from a pre-existing, T cell restricted cytoplasmic factor and an inducible ubiquitous nuclear component within 30 min after activation through the antigen receptor.
T3 419-518 Sentence denotes Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex.
T3 419-518 Sentence denotes Recent studies have implicated the family of AP1 factors as components of the murine NF-AT complex.
T4 519-659 Sentence denotes Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos).
T4 519-659 Sentence denotes Evidence is provided here that the nuclear component of human NF-AT contains the phorbol ester-inducible transcription factor AP1 (Jun/Fos).
T5 660-730 Sentence denotes We further characterize which AP1 family members can assume this role.
T5 660-730 Sentence denotes We further characterize which AP1 family members can assume this role.
T6 731-835 Sentence denotes Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1.
T6 731-835 Sentence denotes Antisera to Fos inhibits NF-AT DNA binding as does an oligonucleotide containing a binding site for AP1.
T7 836-1063 Sentence denotes Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.
T7 836-1063 Sentence denotes Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.
T8 1064-1311 Sentence denotes Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component.
T8 1064-1311 Sentence denotes Overexpression of cJun or JunD, but not JunB, also eliminates the requirement for PMA, indicating that many but not all Jun- and Fos-related proteins functionally activate NF-AT-dependent transcription in the presence of the cytoplasmic component.
T9 1312-1431 Sentence denotes NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes.
T9 1312-1431 Sentence denotes NF-AT DNA binding can be reconstituted in vitro using semi-purified AP1 proteins mixed with cytosol from T lymphocytes.
T10 1432-1574 Sentence denotes Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex.
T10 1432-1574 Sentence denotes Fos proteins are not needed for this reconstitution, and although JunB is not functional, it can participate in the NF-AT DNA binding complex.
T11 1575-1836 Sentence denotes Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.
T11 1575-1836 Sentence denotes Finally, we have partially purified the cytoplasmic component of NF-AT and show by elution and renaturation from SDS-polyacrylamide gel electrophoresis gels that it has a molecular mass between 94 and 116 kDa and may have multiple differentially modified forms.