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PubMed:8394344 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP.
T1 0-96 Sentence denotes Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP.
T2 97-216 Sentence denotes We examined the effects of increasing intracellular cyclic AMP levels on the expression of human PAF receptor (hPAF-R).
T2 97-216 Sentence denotes We examined the effects of increasing intracellular cyclic AMP levels on the expression of human PAF receptor (hPAF-R).
T3 217-293 Sentence denotes Peripheral blood monocytes constitutively expressed hPAF-R mRNA transcripts.
T3 217-293 Sentence denotes Peripheral blood monocytes constitutively expressed hPAF-R mRNA transcripts.
T4 294-463 Sentence denotes A transiently elevated intracellular concentration of AMP induced with prostaglandin E2, cholera toxin, or forskolin was a sufficient signal to inhibit PAF-R expression.
T4 294-463 Sentence denotes A transiently elevated intracellular concentration of AMP induced with prostaglandin E2, cholera toxin, or forskolin was a sufficient signal to inhibit PAF-R expression.
T5 464-680 Sentence denotes To determine the mechanisms of this inhibition, human monocytes were treated with dibutyryl cAMP, a cell-permeable cAMP analogue. cAMP reduced the expression of hPAF-R in a concentration- and a time-dependent manner.
T5 464-680 Sentence denotes To determine the mechanisms of this inhibition, human monocytes were treated with dibutyryl cAMP, a cell-permeable cAMP analogue. cAMP reduced the expression of hPAF-R in a concentration- and a time-dependent manner.
T6 681-750 Sentence denotes The effect was seen as early as 1 h and was essentially total by 4 h.
T6 681-750 Sentence denotes The effect was seen as early as 1 h and was essentially total by 4 h.
T7 751-871 Sentence denotes Stability of hPAF-R mRNA was not markedly decreased by cAMP, as assessed by measuring the half-lives of the transcripts.
T7 751-871 Sentence denotes Stability of hPAF-R mRNA was not markedly decreased by cAMP, as assessed by measuring the half-lives of the transcripts.
T8 872-991 Sentence denotes Moreover, the nuclear transcription rate of the hPAF-R gene was reduced as early as 30 min after stimulation with cAMP.
T8 872-991 Sentence denotes Moreover, the nuclear transcription rate of the hPAF-R gene was reduced as early as 30 min after stimulation with cAMP.
T9 992-1296 Sentence denotes The inhibition of hPAF-R mRNA accumulation was associated with diminished responsiveness to PAF, as assayed by intracellular Ca2+ fluxes, decreased number of binding sites, and decreased hPAF-R protein expression on the cell surface, as assessed by flow cytometry using a polyclonal anti-hPAF-R antibody.
T9 992-1296 Sentence denotes The inhibition of hPAF-R mRNA accumulation was associated with diminished responsiveness to PAF, as assayed by intracellular Ca2+ fluxes, decreased number of binding sites, and decreased hPAF-R protein expression on the cell surface, as assessed by flow cytometry using a polyclonal anti-hPAF-R antibody.
T10 1297-1455 Sentence denotes These data indicate that PAF-R expression can be regulated at the transcriptional and possibly post-transcriptional levels by elevation of intracellular cAMP.
T10 1297-1455 Sentence denotes These data indicate that PAF-R expression can be regulated at the transcriptional and possibly post-transcriptional levels by elevation of intracellular cAMP.