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PubMed:8388392 JSONTXT 22 Projects

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Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
T1 0-122 Sentence denotes Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
T2 123-233 Sentence denotes Mitogen-induced signal transduction is mediated by a cascade of protein phosphorylation and dephosphorylation.
T2 123-233 Sentence denotes Mitogen-induced signal transduction is mediated by a cascade of protein phosphorylation and dephosphorylation.
T3 234-426 Sentence denotes One of the immediate responses of mitogen stimulation is the activation of a family of protein kinases known as mitogen-activated protein kinase or extracellular signal-regulated kinase (ERK).
T3 234-426 Sentence denotes One of the immediate responses of mitogen stimulation is the activation of a family of protein kinases known as mitogen-activated protein kinase or extracellular signal-regulated kinase (ERK).
T4 427-508 Sentence denotes MEK (MAP kinase or ERK kinase) is the immediate upstream activator kinase of ERK.
T4 427-508 Sentence denotes MEK (MAP kinase or ERK kinase) is the immediate upstream activator kinase of ERK.
T5 509-561 Sentence denotes Two cDNAs, MEK1 and MEK2, were cloned and sequenced.
T5 509-561 Sentence denotes Two cDNAs, MEK1 and MEK2, were cloned and sequenced.
T6 562-629 Sentence denotes MEK1 and MEK2 encode 393 and 400 amino acid residues, respectively.
T6 562-629 Sentence denotes MEK1 and MEK2 encode 393 and 400 amino acid residues, respectively.
T7 630-730 Sentence denotes The human MEK1 shares 99% amino acid sequence identity with the murine MEK1 and 80% with human MEK2.
T7 630-730 Sentence denotes The human MEK1 shares 99% amino acid sequence identity with the murine MEK1 and 80% with human MEK2.
T8 731-850 Sentence denotes Both MEK1 and MEK2 were expressed in Escherichia coli and shown to be able to activate recombinant human ERK1 in vitro.
T8 731-850 Sentence denotes Both MEK1 and MEK2 were expressed in Escherichia coli and shown to be able to activate recombinant human ERK1 in vitro.
T9 851-1003 Sentence denotes The purified MEK2 protein stimulated threonine and tyrosine phosphorylation on ERK1 and concomitantly activated ERK1 kinase activity more than 100-fold.
T9 851-1003 Sentence denotes The purified MEK2 protein stimulated threonine and tyrosine phosphorylation on ERK1 and concomitantly activated ERK1 kinase activity more than 100-fold.
T10 1004-1109 Sentence denotes The recombinant MEK2 showed lower activity as an ERK activator as compared with MEK purified from tissue.
T10 1004-1109 Sentence denotes The recombinant MEK2 showed lower activity as an ERK activator as compared with MEK purified from tissue.
T11 1110-1199 Sentence denotes However, the recombinant MEK2 can be activated by serum-stimulated cell extract in vitro.
T11 1110-1199 Sentence denotes However, the recombinant MEK2 can be activated by serum-stimulated cell extract in vitro.
T12 1200-1335 Sentence denotes MEKs, in a manner similar to ERKs, are likely to consist of a family of related proteins playing critical roles in signal transduction.
T12 1200-1335 Sentence denotes MEKs, in a manner similar to ERKs, are likely to consist of a family of related proteins playing critical roles in signal transduction.