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PubMed:8383683 JSONTXT 20 Projects

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Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin.
T1 0-118 Sentence denotes Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin.
T2 119-325 Sentence denotes The multipotent drug suramin, which is currently being studied as an anticancer agent, was found to inhibit the interaction between the urokinase-type plasminogen activator (u-PA) and its cellular receptor.
T2 119-325 Sentence denotes The multipotent drug suramin, which is currently being studied as an anticancer agent, was found to inhibit the interaction between the urokinase-type plasminogen activator (u-PA) and its cellular receptor.
T3 326-485 Sentence denotes 50% inhibition of binding was obtained with a suramin concentration between 30 and 60 micrograms/ml when using U937 cells and a ligand concentration of 0.3 nM.
T3 326-485 Sentence denotes 50% inhibition of binding was obtained with a suramin concentration between 30 and 60 micrograms/ml when using U937 cells and a ligand concentration of 0.3 nM.
T4 486-582 Sentence denotes This concentration of the drug is well below the serum levels found in suramin-treated patients.
T4 486-582 Sentence denotes This concentration of the drug is well below the serum levels found in suramin-treated patients.
T5 583-767 Sentence denotes Inhibition of binding was also demonstrated at the molecular level, using chemical cross-linking or an enzyme-linked immunosorbent assay-type technique based on the ligand interaction.
T5 583-767 Sentence denotes Inhibition of binding was also demonstrated at the molecular level, using chemical cross-linking or an enzyme-linked immunosorbent assay-type technique based on the ligand interaction.
T6 768-961 Sentence denotes The inhibition was not caused by a mere polyanion effect since polysulfates such as heparin, heparan sulfate, and pentosan polysulfate were non-inhibitory or showed only a very weak inhibition.
T6 768-961 Sentence denotes The inhibition was not caused by a mere polyanion effect since polysulfates such as heparin, heparan sulfate, and pentosan polysulfate were non-inhibitory or showed only a very weak inhibition.
T7 962-1086 Sentence denotes However, polysulfonated compounds with structures resembling suramin (i.e. trypan blue and Evans blue) did prove inhibitory.
T7 962-1086 Sentence denotes However, polysulfonated compounds with structures resembling suramin (i.e. trypan blue and Evans blue) did prove inhibitory.
T8 1087-1220 Sentence denotes The inhibition found with suramin showed a concentration dependence consistent with a mixed competitive and noncompetitive mechanism.
T8 1087-1220 Sentence denotes The inhibition found with suramin showed a concentration dependence consistent with a mixed competitive and noncompetitive mechanism.
T9 1221-1281 Sentence denotes The off-rate of prebound ligand was accelerated by the drug.
T9 1221-1281 Sentence denotes The off-rate of prebound ligand was accelerated by the drug.
T10 1282-1490 Sentence denotes It is speculated that the present effect may contribute to the anti-invasive properties of suramin by destroying the cellular potential for localized plasminogen activation and proteolytic matrix degradation.
T10 1282-1490 Sentence denotes It is speculated that the present effect may contribute to the anti-invasive properties of suramin by destroying the cellular potential for localized plasminogen activation and proteolytic matrix degradation.