Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-62 |
Sentence |
denotes |
Structural prerequisites for serum amyloid A fibril formation. |
T1 |
0-62 |
Sentence |
denotes |
Structural prerequisites for serum amyloid A fibril formation. |
T2 |
63-199 |
Sentence |
denotes |
Most studies of experimental amyloid A protein (AA) amyloidosis in mice have been performed in type A mice with BALB/c as the prototype. |
T2 |
63-199 |
Sentence |
denotes |
Most studies of experimental amyloid A protein (AA) amyloidosis in mice have been performed in type A mice with BALB/c as the prototype. |
T3 |
200-321 |
Sentence |
denotes |
In these mice the products of two genes, SAA1 and SAA2, are the major apo-SAA isoforms on high density lipoprotein (HDL). |
T3 |
200-321 |
Sentence |
denotes |
In these mice the products of two genes, SAA1 and SAA2, are the major apo-SAA isoforms on high density lipoprotein (HDL). |
T4 |
322-444 |
Sentence |
denotes |
Of these two isoforms, that differ at nine amino acids, only apo-SAA2 is rapidly cleared and deposited as amyloid fibrils. |
T4 |
322-444 |
Sentence |
denotes |
Of these two isoforms, that differ at nine amino acids, only apo-SAA2 is rapidly cleared and deposited as amyloid fibrils. |
T5 |
445-529 |
Sentence |
denotes |
No mouse strain has ever been shown to be completely resistant to amyloid induction. |
T5 |
445-529 |
Sentence |
denotes |
No mouse strain has ever been shown to be completely resistant to amyloid induction. |
T6 |
530-613 |
Sentence |
denotes |
We have found the CE/J mouse strain to be exceedingly resistant to amyloidogenesis. |
T6 |
530-613 |
Sentence |
denotes |
We have found the CE/J mouse strain to be exceedingly resistant to amyloidogenesis. |
T7 |
614-755 |
Sentence |
denotes |
Data indicate that this resistance is not due to a lack of apo-SAA synthesis but rather resides in the unique apo-SAA isoform in this strain. |
T7 |
614-755 |
Sentence |
denotes |
Data indicate that this resistance is not due to a lack of apo-SAA synthesis but rather resides in the unique apo-SAA isoform in this strain. |
T8 |
756-841 |
Sentence |
denotes |
CE/J mice have a single major apo-SAA isoform (pI 6.15) the product of a single gene. |
T8 |
756-841 |
Sentence |
denotes |
CE/J mice have a single major apo-SAA isoform (pI 6.15) the product of a single gene. |
T9 |
842-963 |
Sentence |
denotes |
This is a hybrid molecule with features of both apo-SAA1 and apo-SAA2, differing from the latter at only six amino acids. |
T9 |
842-963 |
Sentence |
denotes |
This is a hybrid molecule with features of both apo-SAA1 and apo-SAA2, differing from the latter at only six amino acids. |
T10 |
964-1219 |
Sentence |
denotes |
When CD studies were performed to explore the structural relationship of this isoform to apo-SAA1 and apo-SAA2, we found that when bound to heparan sulfate proteoglycan the CE/J pI 6.15 isoform fails to undergo the beta-sheet folding typical for apo-SAA2. |
T10 |
964-1219 |
Sentence |
denotes |
When CD studies were performed to explore the structural relationship of this isoform to apo-SAA1 and apo-SAA2, we found that when bound to heparan sulfate proteoglycan the CE/J pI 6.15 isoform fails to undergo the beta-sheet folding typical for apo-SAA2. |
T11 |
1220-1345 |
Sentence |
denotes |
This evidence suggests that the folding effect of heparan sulfate proteoglycan on apo-SAA2 is important in amyloid formation. |
T11 |
1220-1345 |
Sentence |
denotes |
This evidence suggests that the folding effect of heparan sulfate proteoglycan on apo-SAA2 is important in amyloid formation. |