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PubMed:8376405 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-133 Sentence denotes Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.
T1 0-133 Sentence denotes Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.
TextSentencer_T2 134-272 Sentence denotes Type IIB von Willebrand disease is characterized by increased affinity of mutant von Willebrand factor (vWF) for platelet glycoprotein Ib.
T2 134-272 Sentence denotes Type IIB von Willebrand disease is characterized by increased affinity of mutant von Willebrand factor (vWF) for platelet glycoprotein Ib.
TextSentencer_T3 273-523 Sentence denotes Eight different missense mutations that cause this phenotype have been reported within the disulfide loop defined by Cys-509 and Cys-695 of the mature vWF subunit; this disulfide loop is required for normal binding of vWF to platelet glycoprotein Ib.
T3 273-523 Sentence denotes Eight different missense mutations that cause this phenotype have been reported within the disulfide loop defined by Cys-509 and Cys-695 of the mature vWF subunit; this disulfide loop is required for normal binding of vWF to platelet glycoprotein Ib.
TextSentencer_T4 524-848 Sentence denotes A new mutation was identified in a patient with type IIB von Willebrand disease (vWD) characterized by a lifelong bleeding disorder, mild thrombocytopenia, normal levels of factor VIII, vWF antigen, and ristocetin cofactor activity but increased ristocetin-induced platelet agglutination at low concentrations of ristocetin.
T4 524-848 Sentence denotes A new mutation was identified in a patient with type IIB von Willebrand disease (vWD) characterized by a lifelong bleeding disorder, mild thrombocytopenia, normal levels of factor VIII, vWF antigen, and ristocetin cofactor activity but increased ristocetin-induced platelet agglutination at low concentrations of ristocetin.
TextSentencer_T5 849-920 Sentence denotes Exon 28 of the patient's vWF gene was amplified, cloned, and sequenced.
T5 849-920 Sentence denotes Exon 28 of the patient's vWF gene was amplified, cloned, and sequenced.
TextSentencer_T6 921-1094 Sentence denotes At nucleotide 3802 (numbering the cDNA from translation initiation), a C to G transversion was identified, which changes the encoded amino acid sequence from His-505 to Asp.
T6 921-1094 Sentence denotes At nucleotide 3802 (numbering the cDNA from translation initiation), a C to G transversion was identified, which changes the encoded amino acid sequence from His-505 to Asp.
TextSentencer_T7 1095-1187 Sentence denotes The corresponding mutant recombinant vWF was expressed in transiently transfected COS cells.
T7 1095-1187 Sentence denotes The corresponding mutant recombinant vWF was expressed in transiently transfected COS cells.
TextSentencer_T8 1188-1414 Sentence denotes Relative to wild type vWF, the mutant vWF exhibited markedly increased binding to platelets at low concentrations of ristocetin, confirming the association between the His-505-->Asp substitution and the type IIB vWD phenotype.
T8 1188-1414 Sentence denotes Relative to wild type vWF, the mutant vWF exhibited markedly increased binding to platelets at low concentrations of ristocetin, confirming the association between the His-505-->Asp substitution and the type IIB vWD phenotype.
TextSentencer_T9 1415-1605 Sentence denotes The His-505-->Asp mutation lies outside the disulfide loop affected by other type IIB vWD mutations and implicates a new segment of vWF in the regulation of platelet glycoprotein Ib binding.
T9 1415-1605 Sentence denotes The His-505-->Asp mutation lies outside the disulfide loop affected by other type IIB vWD mutations and implicates a new segment of vWF in the regulation of platelet glycoprotein Ib binding.