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Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.
T1 0-88 Sentence denotes Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.
T2 89-423 Sentence denotes 12(S)-Hydroxyeicosatetraenoic acid is biosynthesized from arachidonic acid by the microsomal fraction of human epidermoid carcinoma A431 cells, and the microsomal 12-lipoxygenase activity is enhanced by about 2-fold by epidermal growth factor (EGF) with a 10-h lag period (Chang, W.C., Ning, C.C., Lin, M.T., and Huang, J.D. (1992) J.
T2 89-423 Sentence denotes 12(S)-Hydroxyeicosatetraenoic acid is biosynthesized from arachidonic acid by the microsomal fraction of human epidermoid carcinoma A431 cells, and the microsomal 12-lipoxygenase activity is enhanced by about 2-fold by epidermal growth factor (EGF) with a 10-h lag period (Chang, W.C., Ning, C.C., Lin, M.T., and Huang, J.D. (1992) J.
T3 424-429 Sentence denotes Biol.
T3 424-429 Sentence denotes Biol.
T4 430-435 Sentence denotes Chem.
T4 430-435 Sentence denotes Chem.
T5 436-452 Sentence denotes 267, 3657-3666).
T5 436-452 Sentence denotes 267, 3657-3666).
T6 453-570 Sentence denotes The microsomal 12-lipoxygenase in A431 cells was only 3% active with linoleic acid as compared with arachidonic acid.
T6 453-570 Sentence denotes The microsomal 12-lipoxygenase in A431 cells was only 3% active with linoleic acid as compared with arachidonic acid.
T7 571-718 Sentence denotes The enzyme was immunoprecipitated by a monoclonal antibody against human platelet 12-lipoxygenase but not by that against porcine leukocyte enzyme.
T7 571-718 Sentence denotes The enzyme was immunoprecipitated by a monoclonal antibody against human platelet 12-lipoxygenase but not by that against porcine leukocyte enzyme.
T8 719-843 Sentence denotes A 3.1-kilobase mRNA was detected in A431 cells by Northern blot analyses using cDNA probe of human platelet 12-lipoxygenase.
T8 719-843 Sentence denotes A 3.1-kilobase mRNA was detected in A431 cells by Northern blot analyses using cDNA probe of human platelet 12-lipoxygenase.
T9 844-1002 Sentence denotes EGF could increase the 12-lipoxygenase mRNA level by about 2-fold with a lag period of 10 h, which was well parallel with the increase in the enzyme activity.
T9 844-1002 Sentence denotes EGF could increase the 12-lipoxygenase mRNA level by about 2-fold with a lag period of 10 h, which was well parallel with the increase in the enzyme activity.
T10 1003-1263 Sentence denotes The induction of the 12-lipoxygenase mRNA by EGF was completely blocked by 35 microM cycloheximide, if present in culture medium during EGF treatment, indicating that a de novo protein biosynthesis was essential for EGF-induced 12-lipoxygenase mRNA expression.
T10 1003-1263 Sentence denotes The induction of the 12-lipoxygenase mRNA by EGF was completely blocked by 35 microM cycloheximide, if present in culture medium during EGF treatment, indicating that a de novo protein biosynthesis was essential for EGF-induced 12-lipoxygenase mRNA expression.
T11 1264-1381 Sentence denotes Our data provide the first evidence for the inducibility of human 12-lipoxygenase gene expression by a growth factor.
T11 1264-1381 Sentence denotes Our data provide the first evidence for the inducibility of human 12-lipoxygenase gene expression by a growth factor.