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Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase.
T1 0-81 Sentence denotes Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase.
T2 82-146 Sentence denotes Functional specificity among G-protein coupled receptor kinases.
T2 82-146 Sentence denotes Functional specificity among G-protein coupled receptor kinases.
T3 147-396 Sentence denotes The thrombin receptor, a member of the seven membrane-spanning superfamily of G-protein coupled receptors, is activated by an irreversible proteolytic mechanism, but signaling by activated thrombin receptors shuts off soon after receptor activation.
T3 147-396 Sentence denotes The thrombin receptor, a member of the seven membrane-spanning superfamily of G-protein coupled receptors, is activated by an irreversible proteolytic mechanism, but signaling by activated thrombin receptors shuts off soon after receptor activation.
T4 397-564 Sentence denotes This shut-off mechanism is thought to be required for concentration-dependent responses to thrombin and an important determinant of the cell's sensitivity to thrombin.
T4 397-564 Sentence denotes This shut-off mechanism is thought to be required for concentration-dependent responses to thrombin and an important determinant of the cell's sensitivity to thrombin.
T5 565-711 Sentence denotes We report that the thrombin receptor is rapidly phosphorylated upon activation, consistent with the action of a G-protein-coupled receptor kinase.
T5 565-711 Sentence denotes We report that the thrombin receptor is rapidly phosphorylated upon activation, consistent with the action of a G-protein-coupled receptor kinase.
T6 712-873 Sentence denotes Moreover, the G-protein coupled receptor kinase BARK2 (beta-adrenergic receptor kinase 2) blocked signaling by thrombin receptors coexpressed in Xenopus oocytes.
T6 712-873 Sentence denotes Moreover, the G-protein coupled receptor kinase BARK2 (beta-adrenergic receptor kinase 2) blocked signaling by thrombin receptors coexpressed in Xenopus oocytes.
T7 874-969 Sentence denotes In this system, rhodopsin kinase was inactive and BARK1 was markedly less effective than BARK2.
T7 874-969 Sentence denotes In this system, rhodopsin kinase was inactive and BARK1 was markedly less effective than BARK2.
T8 970-1208 Sentence denotes Thrombin receptor mutants which lacked potential serine and threonine phosphorylation sites in the receptor's cytoplasmic tail were insensitive to inhibition by exogenous BARK2 but did confer concentration-dependent responses to thrombin.
T8 970-1208 Sentence denotes Thrombin receptor mutants which lacked potential serine and threonine phosphorylation sites in the receptor's cytoplasmic tail were insensitive to inhibition by exogenous BARK2 but did confer concentration-dependent responses to thrombin.
T9 1209-1380 Sentence denotes Our studies demonstrate that a G-protein coupled receptor kinase can shut off thrombin receptor signaling but that additional mechanism(s) for terminating signaling exist.
T9 1209-1380 Sentence denotes Our studies demonstrate that a G-protein coupled receptor kinase can shut off thrombin receptor signaling but that additional mechanism(s) for terminating signaling exist.
T10 1381-1617 Sentence denotes These studies also reveal functional specificity among G-protein coupled receptor kinases in a novel in vivo reconstitution system and show that heterologous expression of these kinases can be used to manipulate cellular responsiveness.
T10 1381-1617 Sentence denotes These studies also reveal functional specificity among G-protein coupled receptor kinases in a novel in vivo reconstitution system and show that heterologous expression of these kinases can be used to manipulate cellular responsiveness.