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Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes Identification and characterization of a novel tyrosine kinase from megakaryocytes.
T1 0-83 Sentence denotes Identification and characterization of a novel tyrosine kinase from megakaryocytes.
T2 84-156 Sentence denotes Protein-tyrosine kinases play pivotal roles in cell signal transduction.
T2 84-156 Sentence denotes Protein-tyrosine kinases play pivotal roles in cell signal transduction.
T3 157-299 Sentence denotes We have isolated a cDNA clone encoding a novel human intracytoplasmic tyrosine kinase, termed matk (megakaryocyte-associated tyrosine kinase).
T3 157-299 Sentence denotes We have isolated a cDNA clone encoding a novel human intracytoplasmic tyrosine kinase, termed matk (megakaryocyte-associated tyrosine kinase).
T4 300-383 Sentence denotes Expression of matk mRNA was predominantly found in cells of megakaryocytic lineage.
T4 300-383 Sentence denotes Expression of matk mRNA was predominantly found in cells of megakaryocytic lineage.
T5 384-508 Sentence denotes The matk cDNA clone encodes a polypeptide of 527 amino acids and has closest sequence similarity to the csk tyrosine kinase.
T5 384-508 Sentence denotes The matk cDNA clone encodes a polypeptide of 527 amino acids and has closest sequence similarity to the csk tyrosine kinase.
T6 509-771 Sentence denotes Sequence comparisons also indicate that matk contains src homology region 2 and 3 domains but lacks the NH2-terminal myristylation signal, the negative regulatory tyrosine (Tyr-527), and the autophosphorylation site (Tyr-416) corresponding to those found in src.
T6 509-771 Sentence denotes Sequence comparisons also indicate that matk contains src homology region 2 and 3 domains but lacks the NH2-terminal myristylation signal, the negative regulatory tyrosine (Tyr-527), and the autophosphorylation site (Tyr-416) corresponding to those found in src.
T7 772-902 Sentence denotes Antibodies raised against the NH2 terminus of matk immunoprecipitated a 60-kDa protein from the CMK human megakaryocyte cell line.
T7 772-902 Sentence denotes Antibodies raised against the NH2 terminus of matk immunoprecipitated a 60-kDa protein from the CMK human megakaryocyte cell line.
T8 903-1014 Sentence denotes Expression of matk mRNA was up-regulated in megakaryocytic cells induced to differentiate by the phorbol ester.
T8 903-1014 Sentence denotes Expression of matk mRNA was up-regulated in megakaryocytic cells induced to differentiate by the phorbol ester.
T9 1015-1193 Sentence denotes Based on its restriction in expression and its modulation during in vitro differentiation, it is likely that matk participates in signal transduction during megakaryocytopoiesis.
T9 1015-1193 Sentence denotes Based on its restriction in expression and its modulation during in vitro differentiation, it is likely that matk participates in signal transduction during megakaryocytopoiesis.