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PubMed:8288554 JSONTXT 19 Projects

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Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes Isolation and characterization of the mouse heme oxygenase-1 gene.
T1 0-66 Sentence denotes Isolation and characterization of the mouse heme oxygenase-1 gene.
T2 67-138 Sentence denotes Distal 5' sequences are required for induction by heme or heavy metals.
T2 67-138 Sentence denotes Distal 5' sequences are required for induction by heme or heavy metals.
T3 139-276 Sentence denotes Mouse genomic fragments encoding heme oxygenase-1 (HO-1) were isolated from a recombinant lambda library by in situ plaque hybridization.
T3 139-276 Sentence denotes Mouse genomic fragments encoding heme oxygenase-1 (HO-1) were isolated from a recombinant lambda library by in situ plaque hybridization.
T4 277-386 Sentence denotes The mouse HO-1 gene, approximately 7 kilobase pairs (kbp) in length, is organized into 5 exons and 4 introns.
T4 277-386 Sentence denotes The mouse HO-1 gene, approximately 7 kilobase pairs (kbp) in length, is organized into 5 exons and 4 introns.
T5 387-488 Sentence denotes The primary structure of the exons and 1287 base pairs (bp) of the 5'-flanking region was determined.
T5 387-488 Sentence denotes The primary structure of the exons and 1287 base pairs (bp) of the 5'-flanking region was determined.
T6 489-647 Sentence denotes The deduced amino acid sequence of the mouse HO-1 gene is identical to that of p32, initially identified as a stress-induced protein in mouse BALBc/3T3 cells.
T6 489-647 Sentence denotes The deduced amino acid sequence of the mouse HO-1 gene is identical to that of p32, initially identified as a stress-induced protein in mouse BALBc/3T3 cells.
T7 648-809 Sentence denotes A single, major transcription initiation site is utilized for constitutive and heme- or metal-induced expression of the HO-1 gene in mouse hepatoma (Hepa) cells.
T7 648-809 Sentence denotes A single, major transcription initiation site is utilized for constitutive and heme- or metal-induced expression of the HO-1 gene in mouse hepatoma (Hepa) cells.
T8 810-979 Sentence denotes The transcriptional activity of the 5'-flanking region was examined by transient expression assays using the chloramphenicol acetyltransferase gene as the reporter gene.
T8 810-979 Sentence denotes The transcriptional activity of the 5'-flanking region was examined by transient expression assays using the chloramphenicol acetyltransferase gene as the reporter gene.
T9 980-1103 Sentence denotes Basal promoter activity in several cell lines was localized to within 149 bp of the upstream sequence by deletion analysis.
T9 980-1103 Sentence denotes Basal promoter activity in several cell lines was localized to within 149 bp of the upstream sequence by deletion analysis.
T10 1104-1378 Sentence denotes This proximal promoter region of the mouse HO-1 gene contains several sequence elements that are not only conserved in both the rat and human HO-1 genes but also resemble consensus binding sites of various transcription factors including AP-1, AP-4, C/EBP and c-Myc:Max/USF.
T10 1104-1378 Sentence denotes This proximal promoter region of the mouse HO-1 gene contains several sequence elements that are not only conserved in both the rat and human HO-1 genes but also resemble consensus binding sites of various transcription factors including AP-1, AP-4, C/EBP and c-Myc:Max/USF.
T11 1379-1498 Sentence denotes Heavy metals activate HO-1 gene transcription and the rat gene contains a putative metal regulatory element (Müller, R.
T11 1379-1498 Sentence denotes Heavy metals activate HO-1 gene transcription and the rat gene contains a putative metal regulatory element (Müller, R.
T12 1499-1543 Sentence denotes M., Taguchi, H., and Shibahara, S. (1987) J.
T12 1499-1543 Sentence denotes M., Taguchi, H., and Shibahara, S. (1987) J.
T13 1544-1549 Sentence denotes Biol.
T13 1544-1549 Sentence denotes Biol.
T14 1550-1555 Sentence denotes Chem.
T14 1550-1555 Sentence denotes Chem.
T15 1556-1619 Sentence denotes 262, 6795-6802) that is completely conserved in the mouse gene.
T15 1556-1619 Sentence denotes 262, 6795-6802) that is completely conserved in the mouse gene.
T16 1620-1868 Sentence denotes Transient expression analyses, however, indicate that this sequence, which contains a core heptanucleotide, TGCACTC, identical to that of the strongest metal regulatory element of the mouse metallothionein-1 gene, is not responsive to Cd2+ or Zn2+.
T16 1620-1868 Sentence denotes Transient expression analyses, however, indicate that this sequence, which contains a core heptanucleotide, TGCACTC, identical to that of the strongest metal regulatory element of the mouse metallothionein-1 gene, is not responsive to Cd2+ or Zn2+.
T17 1869-2248 Sentence denotes Stable transfection of constructs containing the entire mouse HO-1 gene and various portions of the 5'-flanking region into rat C6 glioma cells and simultaneous, quantitative analysis of the mouse and rat HO-1 mRNAs indicate that distal 5' sequences, between positions -3.5 and -12.5 kbp, are required for induction of mouse HO-1 gene transcription by both heme and heavy metals.
T17 1869-2248 Sentence denotes Stable transfection of constructs containing the entire mouse HO-1 gene and various portions of the 5'-flanking region into rat C6 glioma cells and simultaneous, quantitative analysis of the mouse and rat HO-1 mRNAs indicate that distal 5' sequences, between positions -3.5 and -12.5 kbp, are required for induction of mouse HO-1 gene transcription by both heme and heavy metals.
T18 2249-2440 Sentence denotes A 5-7-fold difference in the levels of induction between stably integrated and transiently expressed mouse HO-1 gene constructs is observed in this cell line.(ABSTRACT TRUNCATED AT 400 WORDS)
T18 2249-2440 Sentence denotes A 5-7-fold difference in the levels of induction between stably integrated and transiently expressed mouse HO-1 gene constructs is observed in this cell line.(ABSTRACT TRUNCATED AT 400 WORDS)