| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-64 |
Sentence |
denotes |
A novel heterodimerization partner for thyroid hormone receptor. |
| T1 |
0-64 |
Sentence |
denotes |
A novel heterodimerization partner for thyroid hormone receptor. |
| T2 |
65-108 |
Sentence |
denotes |
Peroxisome proliferator-activated receptor. |
| T2 |
65-108 |
Sentence |
denotes |
Peroxisome proliferator-activated receptor. |
| T3 |
109-236 |
Sentence |
denotes |
Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors. |
| T3 |
109-236 |
Sentence |
denotes |
Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors. |
| T4 |
237-429 |
Sentence |
denotes |
In this study we have identified the peroxisome proliferator-activated receptor (PPAR) as a new thyroid hormone receptor (THR) auxiliary nuclear protein, heterodimerizing with THR in solution. |
| T4 |
237-429 |
Sentence |
denotes |
In this study we have identified the peroxisome proliferator-activated receptor (PPAR) as a new thyroid hormone receptor (THR) auxiliary nuclear protein, heterodimerizing with THR in solution. |
| T5 |
430-672 |
Sentence |
denotes |
Although these heterodimers do not recognize a classical thyroid hormone response element (TRE) characterized by direct repeat separated by four nucleotides (DR+4), PPAR behaves as a dominant negative regulator of thyroid hormone (TH) action. |
| T5 |
430-672 |
Sentence |
denotes |
Although these heterodimers do not recognize a classical thyroid hormone response element (TRE) characterized by direct repeat separated by four nucleotides (DR+4), PPAR behaves as a dominant negative regulator of thyroid hormone (TH) action. |
| T6 |
673-834 |
Sentence |
denotes |
However, a TH-dependent positive effect is elicited by selective interaction of the THR beta-PPAR but not the THR alpha-PPAR heterodimer with a novel TRE (DR+2). |
| T6 |
673-834 |
Sentence |
denotes |
However, a TH-dependent positive effect is elicited by selective interaction of the THR beta-PPAR but not the THR alpha-PPAR heterodimer with a novel TRE (DR+2). |
| T7 |
835-939 |
Sentence |
denotes |
The critical region of THR beta was mapped to 3 amino acids in the distal box of the DNA binding domain. |
| T7 |
835-939 |
Sentence |
denotes |
The critical region of THR beta was mapped to 3 amino acids in the distal box of the DNA binding domain. |
| T8 |
940-1044 |
Sentence |
denotes |
Hence, PPAR can positively or negatively influence TH action depending on TRE structure and THR isotype. |
| T8 |
940-1044 |
Sentence |
denotes |
Hence, PPAR can positively or negatively influence TH action depending on TRE structure and THR isotype. |
