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Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.
T1 0-144 Sentence denotes Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes.
T2 145-273 Sentence denotes A large body of evidence indicates that experimental agents which raise cellular cAMP levels inhibit T cell growth and division.
T2 145-273 Sentence denotes A large body of evidence indicates that experimental agents which raise cellular cAMP levels inhibit T cell growth and division.
T3 274-446 Sentence denotes By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process.
T3 274-446 Sentence denotes By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process.
T4 447-641 Sentence denotes In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein (CREB).
T4 447-641 Sentence denotes In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein (CREB).
T5 642-764 Sentence denotes Four complexes are identified by the electrophoretic mobility shift assay, two of which are induced by mitogen activation.
T5 642-764 Sentence denotes Four complexes are identified by the electrophoretic mobility shift assay, two of which are induced by mitogen activation.
T6 765-941 Sentence denotes All four complexes contain CREB and are bound to the cAMP response element (CRE) core sequence (TGACGTCA), as indicated by antibody and oligonucleotide competition experiments.
T6 765-941 Sentence denotes All four complexes contain CREB and are bound to the cAMP response element (CRE) core sequence (TGACGTCA), as indicated by antibody and oligonucleotide competition experiments.
T7 942-1127 Sentence denotes Binding of the four complexes to CRE is prevented by dephosphorylation of nuclear extracts and is restored by rephosphorylation with cAMP-dependent protein kinase or endogenous kinases.
T7 942-1127 Sentence denotes Binding of the four complexes to CRE is prevented by dephosphorylation of nuclear extracts and is restored by rephosphorylation with cAMP-dependent protein kinase or endogenous kinases.
T8 1128-1195 Sentence denotes Similar complexes are detected in nuclear extracts of Jurkat cells.
T8 1128-1195 Sentence denotes Similar complexes are detected in nuclear extracts of Jurkat cells.
T9 1196-1340 Sentence denotes Mitogen induction of the electrophoretic mobility shift assay complexes is not accounted for by protein phosphorylation or by induction of CREB.
T9 1196-1340 Sentence denotes Mitogen induction of the electrophoretic mobility shift assay complexes is not accounted for by protein phosphorylation or by induction of CREB.
T10 1341-1449 Sentence denotes Rather, the data indicate that mitogen increases the levels of a nuclear factor(s) that dimerizes with CREB.
T10 1341-1449 Sentence denotes Rather, the data indicate that mitogen increases the levels of a nuclear factor(s) that dimerizes with CREB.
T11 1450-1559 Sentence denotes Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes.
T11 1450-1559 Sentence denotes Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes.