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PubMed:7961890 JSONTXT 36 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Cloned beta 1,4 N-acetylgalactosaminyltransferase synthesizes GA2 as well as gangliosides GM2 and GD2.
T1 0-102 Sentence denotes Cloned beta 1,4 N-acetylgalactosaminyltransferase synthesizes GA2 as well as gangliosides GM2 and GD2.
T2 103-203 Sentence denotes GM3 synthesis has priority over GA2 synthesis for utilization of lactosylceramide substrate in vivo.
T2 103-203 Sentence denotes GM3 synthesis has priority over GA2 synthesis for utilization of lactosylceramide substrate in vivo.
T3 204-418 Sentence denotes Earlier studies reached conflicting conclusions as to the ability of the beta 1,4 N-acetylgalactosaminyltransferase (GalNAc-T) that synthesizes gangliosides GM2 and GD2 to also produce gangliotriosylceramide (GA2).
T3 204-418 Sentence denotes Earlier studies reached conflicting conclusions as to the ability of the beta 1,4 N-acetylgalactosaminyltransferase (GalNAc-T) that synthesizes gangliosides GM2 and GD2 to also produce gangliotriosylceramide (GA2).
T4 419-491 Sentence denotes We constructed an experimental system in which to address this question.
T4 419-491 Sentence denotes We constructed an experimental system in which to address this question.
T5 492-743 Sentence denotes Wild type Chinese hamster ovary (CHO) cells contain ganglioside GM3 as the most complex glycosphingolipid (GSL), whereas the CHO glycosylation mutant Lec2, which is deficient in sialylation, accumulates lactosylceramide with little GM3 being produced.
T5 492-743 Sentence denotes Wild type Chinese hamster ovary (CHO) cells contain ganglioside GM3 as the most complex glycosphingolipid (GSL), whereas the CHO glycosylation mutant Lec2, which is deficient in sialylation, accumulates lactosylceramide with little GM3 being produced.
T6 744-819 Sentence denotes We transfected both cell types with a plasmid containing a cloned GalNAc-T.
T6 744-819 Sentence denotes We transfected both cell types with a plasmid containing a cloned GalNAc-T.
T7 820-941 Sentence denotes Whereas transfected CHO cells produced GM2 as the major complex GSL, the major product in transfected Lec2 cells was GA2.
T7 820-941 Sentence denotes Whereas transfected CHO cells produced GM2 as the major complex GSL, the major product in transfected Lec2 cells was GA2.
T8 942-1125 Sentence denotes Both types of transfected cells but not the untransfected cells expressed the transfected gene and contained high levels of enzyme activity for synthesizing both GM2 and GA2 in vitro.
T8 942-1125 Sentence denotes Both types of transfected cells but not the untransfected cells expressed the transfected gene and contained high levels of enzyme activity for synthesizing both GM2 and GA2 in vitro.
T9 1126-1228 Sentence denotes In summary, these results indicate that this enzyme can in fact synthesize GA2 as well as GM2 and GD2.
T9 1126-1228 Sentence denotes In summary, these results indicate that this enzyme can in fact synthesize GA2 as well as GM2 and GD2.
T10 1229-1477 Sentence denotes In addition, these findings suggest that in CHO cells the synthesis of GM3 in vivo has priority over GA2 synthesis for utilization of the substrate lactosylceramide, resulting in little GA2 being produced even though GalNAc-T is present and active.
T10 1229-1477 Sentence denotes In addition, these findings suggest that in CHO cells the synthesis of GM3 in vivo has priority over GA2 synthesis for utilization of the substrate lactosylceramide, resulting in little GA2 being produced even though GalNAc-T is present and active.
T11 1478-1595 Sentence denotes Thus, competition for substrate between glycosylation pathways may have profound effects on the GSL pattern of cells.
T11 1478-1595 Sentence denotes Thus, competition for substrate between glycosylation pathways may have profound effects on the GSL pattern of cells.