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PubMed:7895225 JSONTXT 37 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-81 Sentence denotes Structural and functional-group tuning in the design of neuraminidase inhibitors.
T1 0-81 Sentence denotes Structural and functional-group tuning in the design of neuraminidase inhibitors.
TextSentencer_T2 82-319 Sentence denotes Analogues of the disaccharide alpha-NeuAc-(2-->6)-beta-D-Gal-OR have been made by modifications at C-1 and C-6 of the galactose and at C-4 of the NeuAc unit, for structure-activity relationship studies with influenza virus neuraminidase.
T2 82-319 Sentence denotes Analogues of the disaccharide alpha-NeuAc-(2-->6)-beta-D-Gal-OR have been made by modifications at C-1 and C-6 of the galactose and at C-4 of the NeuAc unit, for structure-activity relationship studies with influenza virus neuraminidase.
TextSentencer_T3 320-547 Sentence denotes These studies indicate that for the influenza neuraminidase, a larger aglycon at C-1 of galactose is less preferred, whereas the restriction of the rotamer orientation at C-6 of galactose in the "tg" mode favors enzyme binding.
T3 320-547 Sentence denotes These studies indicate that for the influenza neuraminidase, a larger aglycon at C-1 of galactose is less preferred, whereas the restriction of the rotamer orientation at C-6 of galactose in the "tg" mode favors enzyme binding.
TextSentencer_T4 548-672 Sentence denotes Substitution at C-4 of the NeuAc unit has the most profound effect in the influenza neuraminidase hydrolysis and inhibition.
T4 548-672 Sentence denotes Substitution at C-4 of the NeuAc unit has the most profound effect in the influenza neuraminidase hydrolysis and inhibition.
TextSentencer_T5 673-799 Sentence denotes For example, azido and acetamido groups at C-4 of the NeuAc units render the sialosides resistant to neuraminidase hydrolysis.
T5 673-799 Sentence denotes For example, azido and acetamido groups at C-4 of the NeuAc units render the sialosides resistant to neuraminidase hydrolysis.
TextSentencer_T6 800-901 Sentence denotes However, these derivatives are not inhibitors of the neuraminidase, indicating their lack of binding.
T6 800-901 Sentence denotes However, these derivatives are not inhibitors of the neuraminidase, indicating their lack of binding.
TextSentencer_T7 902-1085 Sentence denotes On the other hand, a 4-amino substitution of the NeuAc unit not only renders the corresponding sialosides neuraminidase-resistant, but also makes them potent neuraminidase inhibitors.
T7 902-1085 Sentence denotes On the other hand, a 4-amino substitution of the NeuAc unit not only renders the corresponding sialosides neuraminidase-resistant, but also makes them potent neuraminidase inhibitors.
TextSentencer_T8 1086-1249 Sentence denotes This potent inhibition indicates that the 4-amino groups in these sialosides may engage in favorable interaction with amino acids at the neuraminidase active-site.
T8 1086-1249 Sentence denotes This potent inhibition indicates that the 4-amino groups in these sialosides may engage in favorable interaction with amino acids at the neuraminidase active-site.
TextSentencer_T9 1250-1366 Sentence denotes The conclusion is also supported by docking studies of the carbohydrate structures at the neuraminidase active-site.
T9 1250-1366 Sentence denotes The conclusion is also supported by docking studies of the carbohydrate structures at the neuraminidase active-site.