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PubMed:7890777 JSONTXT 28 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-169 Sentence denotes Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
T1 0-169 Sentence denotes Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
T2 170-301 Sentence denotes We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.
T2 170-301 Sentence denotes We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP.
T3 302-431 Sentence denotes Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.
T3 302-431 Sentence denotes Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor.
T4 432-633 Sentence denotes Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.
T4 432-633 Sentence denotes Indeed, transient transfection of HLA-DRA and DQB reporter constructs indicated that the affected factor operates via cis-elements located between -141 base pairs and the transcription initiation site.
T5 634-751 Sentence denotes A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.
T5 634-751 Sentence denotes A series of hybrid DRA/DQB reporter constructs was generated to further map the relevant cis-elements in this system.
T6 752-938 Sentence denotes Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.
T6 752-938 Sentence denotes Insertion of oligonucleotides spanning the DQB X-box (but not the DQB-W region or the DQB Y-box) upstream of -141 in a DRA reporter plasmid rescued expression to nearly wild-type levels.
T7 939-1097 Sentence denotes Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.
T7 939-1097 Sentence denotes Substitution promoters were then generated where the entire X-box, or only the X1- or X2-boxes of HLA-DRA were replaced with the analogous regions of HLA-DQB.
T8 1098-1181 Sentence denotes The DQB X2-box was able to restore expression to the silent DRA reporter construct.
T8 1098-1181 Sentence denotes The DQB X2-box was able to restore expression to the silent DRA reporter construct.
T9 1182-1314 Sentence denotes Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.
T9 1182-1314 Sentence denotes Moreover, replacement of the DQB X2-box with the DRA X2-box markedly diminished the activity of the DQB promoter in the mutant cell.
T10 1315-1453 Sentence denotes None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.
T10 1315-1453 Sentence denotes None of the hybrid reporter constructs were defective when transfected into the wild-type, HLA-DR/-DQ positive parental cell line, Jijoye.
T11 1454-1655 Sentence denotes These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.
T11 1454-1655 Sentence denotes These studies suggest that the divergent X2-box of the class II major histocompatibility complex promoters plays an important role in influencing differential expression of the human class II isotypes.