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PubMed:7890671 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex.
T1 0-86 Sentence denotes Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex.
T2 87-137 Sentence denotes Implications for structure-based inhibitor design.
T2 87-137 Sentence denotes Implications for structure-based inhibitor design.
T3 138-299 Sentence denotes The lysosomal cysteine proteinase cathepsin B (EC 3.4.22.1) plays an important role in protein catabolism and has also been implicated in various disease states.
T3 138-299 Sentence denotes The lysosomal cysteine proteinase cathepsin B (EC 3.4.22.1) plays an important role in protein catabolism and has also been implicated in various disease states.
T4 300-395 Sentence denotes The crystal structures of two forms of native recombinant rat cathepsin B have been determined.
T4 300-395 Sentence denotes The crystal structures of two forms of native recombinant rat cathepsin B have been determined.
T5 396-498 Sentence denotes The overall folding of rat cathepsin B was shown to be very similar to that of the human liver enzyme.
T5 396-498 Sentence denotes The overall folding of rat cathepsin B was shown to be very similar to that of the human liver enzyme.
T6 499-695 Sentence denotes The structure of the native enzyme containing an underivatized active site cysteine (Cys29) showed the active enzyme conformation to be similar to that determined previously for the oxidized form.
T6 499-695 Sentence denotes The structure of the native enzyme containing an underivatized active site cysteine (Cys29) showed the active enzyme conformation to be similar to that determined previously for the oxidized form.
T7 696-795 Sentence denotes In a second structure Cys29 was derivatized with the reversible blocking reagent pyridyl disulfide.
T7 696-795 Sentence denotes In a second structure Cys29 was derivatized with the reversible blocking reagent pyridyl disulfide.
T8 796-982 Sentence denotes In this structure large side chain conformational changes were observed for the two key catalytic residues Cys29 and His199, demonstrating the potential flexibility of these side chains.
T8 796-982 Sentence denotes In this structure large side chain conformational changes were observed for the two key catalytic residues Cys29 and His199, demonstrating the potential flexibility of these side chains.
T9 983-1133 Sentence denotes In addition the structure of the complex between rat cathepsin B and the inhibitor benzyloxycarbonyl-Arg-Ser(O-Bzl) chloromethylketone was determined.
T9 983-1133 Sentence denotes In addition the structure of the complex between rat cathepsin B and the inhibitor benzyloxycarbonyl-Arg-Ser(O-Bzl) chloromethylketone was determined.
T10 1134-1246 Sentence denotes The complex structure showed that very little conformational change occurs in the enzyme upon inhibitor binding.
T10 1134-1246 Sentence denotes The complex structure showed that very little conformational change occurs in the enzyme upon inhibitor binding.
T11 1247-1329 Sentence denotes It also allowed visualization of the interaction between the enzyme and inhibitor.
T11 1247-1329 Sentence denotes It also allowed visualization of the interaction between the enzyme and inhibitor.
T12 1330-1564 Sentence denotes In particular the interaction between Glu245 and the P2 Arg residue was clearly demonstrated, and it was found that the benzyl group of the P1 substrate residue occupies a large hydrophobic pocket thought to represent the S'1 subsite.
T12 1330-1564 Sentence denotes In particular the interaction between Glu245 and the P2 Arg residue was clearly demonstrated, and it was found that the benzyl group of the P1 substrate residue occupies a large hydrophobic pocket thought to represent the S'1 subsite.
T13 1565-1655 Sentence denotes This may have important implications for structure-based design of cathepsin B inhibitors.
T13 1565-1655 Sentence denotes This may have important implications for structure-based design of cathepsin B inhibitors.