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PubMed:7836389 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-150 Sentence denotes Two distinct signalling pathways are involved in the control of the biphasic junB transcription induced by interleukin-6 in the B cell hybridoma 7TD1.
T1 0-150 Sentence denotes Two distinct signalling pathways are involved in the control of the biphasic junB transcription induced by interleukin-6 in the B cell hybridoma 7TD1.
T2 151-265 Sentence denotes We have measured the level of junB mRNA in the B hybridoma cell line 7TD1, under interleukin-6 (IL-6) stimulation.
T2 151-265 Sentence denotes We have measured the level of junB mRNA in the B hybridoma cell line 7TD1, under interleukin-6 (IL-6) stimulation.
T3 266-313 Sentence denotes IL-6 increases junB mRNA in a biphasic fashion.
T3 266-313 Sentence denotes IL-6 increases junB mRNA in a biphasic fashion.
T4 314-488 Sentence denotes The first early-induced peak was transient and likely corresponds to the well documented typical junB mRNA, stimulated in response to numerous growth factors, including IL-6.
T4 314-488 Sentence denotes The first early-induced peak was transient and likely corresponds to the well documented typical junB mRNA, stimulated in response to numerous growth factors, including IL-6.
T5 489-581 Sentence denotes At variance, the second peak which has never been reported previously, lasted several hours.
T5 489-581 Sentence denotes At variance, the second peak which has never been reported previously, lasted several hours.
T6 582-712 Sentence denotes As a consequence of its effect on junB mRNA, IL-6 stimulated, in a biphasic fashion, the nuclear accumulation of the JunB protein.
T6 582-712 Sentence denotes As a consequence of its effect on junB mRNA, IL-6 stimulated, in a biphasic fashion, the nuclear accumulation of the JunB protein.
T7 713-944 Sentence denotes In this study, we demonstrated that IL-6 regulation occurred exclusively at the transcriptional level and that the bimodal increase of junB mRNA and JunB protein can be accounted for by a biphasic stimulation of junB transcription.
T7 713-944 Sentence denotes In this study, we demonstrated that IL-6 regulation occurred exclusively at the transcriptional level and that the bimodal increase of junB mRNA and JunB protein can be accounted for by a biphasic stimulation of junB transcription.
T8 945-1095 Sentence denotes Furthermore, our data point to two major differences between the mechanism of control of the early and the late IL-6-induced junB transcription waves.
T8 945-1095 Sentence denotes Furthermore, our data point to two major differences between the mechanism of control of the early and the late IL-6-induced junB transcription waves.
T9 1096-1228 Sentence denotes First, cycloheximide strongly potentiated the transcription of the second wave, whereas it failed to affect the early-induced burst.
T9 1096-1228 Sentence denotes First, cycloheximide strongly potentiated the transcription of the second wave, whereas it failed to affect the early-induced burst.
T10 1229-1349 Sentence denotes Second, tyrphostin, a tyrosine kinase inhibitor, impaired the expression of the first but not the second junB mRNA peak.
T10 1229-1349 Sentence denotes Second, tyrphostin, a tyrosine kinase inhibitor, impaired the expression of the first but not the second junB mRNA peak.
T11 1350-1532 Sentence denotes Conversely, genistein, another tyrosine kinase inhibitor, totally abolished the expression of the second peak of junB mRNA whereas it did not affect the expression of the first peak.
T11 1350-1532 Sentence denotes Conversely, genistein, another tyrosine kinase inhibitor, totally abolished the expression of the second peak of junB mRNA whereas it did not affect the expression of the first peak.
T12 1533-1687 Sentence denotes Altogether these data indicate that, in 7TD1 cells, IL-6 controls junB transcription in a biphasic fashion by means of two separate transduction pathways.
T12 1533-1687 Sentence denotes Altogether these data indicate that, in 7TD1 cells, IL-6 controls junB transcription in a biphasic fashion by means of two separate transduction pathways.