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PubMed:7829531 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-213 Sentence denotes Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton.
T1 0-213 Sentence denotes Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton.
T2 214-430 Sentence denotes In neurons cAMP-dependent protein kinase II beta (PKAII beta) is sequestered in the dendritic cytoskeleton because the regulatory subunit (RII beta) of the enzyme is tightly bound by A Kinase Anchor Proteins (AKAPs).
T2 214-430 Sentence denotes In neurons cAMP-dependent protein kinase II beta (PKAII beta) is sequestered in the dendritic cytoskeleton because the regulatory subunit (RII beta) of the enzyme is tightly bound by A Kinase Anchor Proteins (AKAPs).
T3 431-542 Sentence denotes The prototypic neuronal anchor protein AKAP75 has a COOH-terminal 22-residue RII beta binding (tethering) site.
T3 431-542 Sentence denotes The prototypic neuronal anchor protein AKAP75 has a COOH-terminal 22-residue RII beta binding (tethering) site.
T4 543-686 Sentence denotes A key feature of the tethering site is that several amino acids with large aliphatic side chains mediate the high-affinity binding of RII beta.
T4 543-686 Sentence denotes A key feature of the tethering site is that several amino acids with large aliphatic side chains mediate the high-affinity binding of RII beta.
T5 687-882 Sentence denotes Mutagenesis, recombinant protein expression, and physicochemical characterization were used to investigate the structural basis for the homodimerization and AKAP75 binding activities of RII beta.
T5 687-882 Sentence denotes Mutagenesis, recombinant protein expression, and physicochemical characterization were used to investigate the structural basis for the homodimerization and AKAP75 binding activities of RII beta.
T6 883-981 Sentence denotes Several crucial residues are located in an NH2-terminal region that encompasses amino acids 13-36.
T6 883-981 Sentence denotes Several crucial residues are located in an NH2-terminal region that encompasses amino acids 13-36.
T7 982-1083 Sentence denotes Substitution of Ala for Leu13 or Phe36 generates monomeric RII beta subunits that cannot bind AKAP75.
T7 982-1083 Sentence denotes Substitution of Ala for Leu13 or Phe36 generates monomeric RII beta subunits that cannot bind AKAP75.
T8 1084-1284 Sentence denotes The results are not due to general misfolding since mutant RII beta monomers bind cAMP and inhibit the catalytic subunit of PKAII beta with the same affinity and efficacy as wild-type RII beta dimers.
T8 1084-1284 Sentence denotes The results are not due to general misfolding since mutant RII beta monomers bind cAMP and inhibit the catalytic subunit of PKAII beta with the same affinity and efficacy as wild-type RII beta dimers.
T9 1285-1445 Sentence denotes Moreover, substitution of Ala for Leu12, Val20, Leu21, Phe31, Leu33, or Leu39 and replacement of Leu13 with Ile or Val did not impair the dimerization reaction.
T9 1285-1445 Sentence denotes Moreover, substitution of Ala for Leu12, Val20, Leu21, Phe31, Leu33, or Leu39 and replacement of Leu13 with Ile or Val did not impair the dimerization reaction.
T10 1446-1571 Sentence denotes Evidently, large hydrophobic side chains of Leu13 and Phe36 play pivotal roles in stabilizing RII beta-RII beta interactions.
T10 1446-1571 Sentence denotes Evidently, large hydrophobic side chains of Leu13 and Phe36 play pivotal roles in stabilizing RII beta-RII beta interactions.
T11 1572-1724 Sentence denotes A secondary consequence of destabilizing RII beta dimers is the loss of intracellular targeting/anchoring capacity because monomers fail to bind AKAP75.
T11 1572-1724 Sentence denotes A secondary consequence of destabilizing RII beta dimers is the loss of intracellular targeting/anchoring capacity because monomers fail to bind AKAP75.
T12 1725-1833 Sentence denotes Other NH2-terminal residues directly modulate the affinity of RII beta dimers for the AKAP75 tethering site.
T12 1725-1833 Sentence denotes Other NH2-terminal residues directly modulate the affinity of RII beta dimers for the AKAP75 tethering site.
T13 1834-1977 Sentence denotes Replacement of Val20-Leu21 with Ala-Ala produced a dimeric RII beta protein that binds AKAP75 approximately 4% as avidly as wild-type RII beta.
T13 1834-1977 Sentence denotes Replacement of Val20-Leu21 with Ala-Ala produced a dimeric RII beta protein that binds AKAP75 approximately 4% as avidly as wild-type RII beta.
T14 1978-2123 Sentence denotes It is possible that the aliphatic side chains of Val20 and Leu21 interact with the essential Leu and Ile residues in the AKAP75 tethering region.
T14 1978-2123 Sentence denotes It is possible that the aliphatic side chains of Val20 and Leu21 interact with the essential Leu and Ile residues in the AKAP75 tethering region.