| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-109 |
Sentence |
denotes |
The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma. |
| T1 |
0-109 |
Sentence |
denotes |
The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma. |
| T2 |
110-229 |
Sentence |
denotes |
We have identified an in vivo footprint over the PuF site on the translocated c-myc allele in Burkitt's lymphoma cells. |
| T2 |
110-229 |
Sentence |
denotes |
We have identified an in vivo footprint over the PuF site on the translocated c-myc allele in Burkitt's lymphoma cells. |
| T3 |
230-292 |
Sentence |
denotes |
The PuF site on the silent normal c-myc allele was unoccupied. |
| T3 |
230-292 |
Sentence |
denotes |
The PuF site on the silent normal c-myc allele was unoccupied. |
| T4 |
293-544 |
Sentence |
denotes |
We demonstrated by electrophoretic mobility shift assay, electrophoretic mobility shift assay with antibody, UV cross-linking followed by SDS-gel electrophoresis, and Western analysis that Nm23H2 in B cell nuclear extracts bound to the c-myc PuF site. |
| T4 |
293-544 |
Sentence |
denotes |
We demonstrated by electrophoretic mobility shift assay, electrophoretic mobility shift assay with antibody, UV cross-linking followed by SDS-gel electrophoresis, and Western analysis that Nm23H2 in B cell nuclear extracts bound to the c-myc PuF site. |
| T5 |
545-763 |
Sentence |
denotes |
Transfection experiments with c-myc promoter constructs in both DHL-9 and Raji cells revealed that the PuF site functioned as a positive regulatory element in B cells with a drop in activity with mutation of this site. |
| T5 |
545-763 |
Sentence |
denotes |
Transfection experiments with c-myc promoter constructs in both DHL-9 and Raji cells revealed that the PuF site functioned as a positive regulatory element in B cells with a drop in activity with mutation of this site. |
| T6 |
764-962 |
Sentence |
denotes |
Access to this site is blocked in the normal silent c-myc allele; these data suggest that the Nm23H2 protein is involved in deregulation of the translocated c-myc allele in Burkitt's lymphoma cells. |
| T6 |
764-962 |
Sentence |
denotes |
Access to this site is blocked in the normal silent c-myc allele; these data suggest that the Nm23H2 protein is involved in deregulation of the translocated c-myc allele in Burkitt's lymphoma cells. |