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PubMed:7738013 JSONTXT 29 Projects

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Id Subject Object Predicate Lexical cue
T1 0-51 Sentence denotes Mouse interleukin-2 receptor alpha gene expression.
T1 0-51 Sentence denotes Mouse interleukin-2 receptor alpha gene expression.
T2 52-139 Sentence denotes Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.
T2 52-139 Sentence denotes Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.
T3 140-293 Sentence denotes We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors.
T3 140-293 Sentence denotes We have shown that interleukin-1 (IL-1) and IL-2 control IL-2 receptor alpha (IL-2R alpha) gene transcription in CD4-CD8- murine T lymphocyte precursors.
T4 294-449 Sentence denotes Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha gene using a thymic lymphoma-derived hybridoma (PC60).
T4 294-449 Sentence denotes Here we map the cis-acting elements that mediate interleukin responsiveness of the mouse IL-2R alpha gene using a thymic lymphoma-derived hybridoma (PC60).
T5 450-545 Sentence denotes The transcriptional response of the IL-2R alpha gene to stimulation by IL-1 + IL-2 is biphasic.
T5 450-545 Sentence denotes The transcriptional response of the IL-2R alpha gene to stimulation by IL-1 + IL-2 is biphasic.
T6 546-684 Sentence denotes IL-1 induces a rapid, protein synthesis-independent appearance of IL-2R alpha mRNA that is blocked by inhibitors of NF-kappa B activation.
T6 546-684 Sentence denotes IL-1 induces a rapid, protein synthesis-independent appearance of IL-2R alpha mRNA that is blocked by inhibitors of NF-kappa B activation.
T7 685-848 Sentence denotes It also primes cells to become IL-2 responsive and thereby prepares the second phase, in which IL-2 induces a 100-fold further increase in IL-2R alpha transcripts.
T7 685-848 Sentence denotes It also primes cells to become IL-2 responsive and thereby prepares the second phase, in which IL-2 induces a 100-fold further increase in IL-2R alpha transcripts.
T8 849-1076 Sentence denotes Transient transfection experiments show that several elements in the promoter-proximal region of the IL-2R alpha gene contribute to IL-1 responsiveness, most importantly an NF-kappa B site conserved in the human and mouse gene.
T8 849-1076 Sentence denotes Transient transfection experiments show that several elements in the promoter-proximal region of the IL-2R alpha gene contribute to IL-1 responsiveness, most importantly an NF-kappa B site conserved in the human and mouse gene.
T9 1077-1213 Sentence denotes IL-2 responsiveness, on the other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream of the major transcription start site.
T9 1077-1213 Sentence denotes IL-2 responsiveness, on the other hand, depends on a 78-nucleotide segment 1.3 kilobases upstream of the major transcription start site.
T10 1214-1395 Sentence denotes This segment functions as an IL-2-inducible enhancer and lies within a region that becomes DNase I hypersensitive in normal T cells in which IL-2R alpha expression has been induced.
T10 1214-1395 Sentence denotes This segment functions as an IL-2-inducible enhancer and lies within a region that becomes DNase I hypersensitive in normal T cells in which IL-2R alpha expression has been induced.
T11 1396-1469 Sentence denotes IL-2 responsiveness requires three distinct elements within the enhancer.
T11 1396-1469 Sentence denotes IL-2 responsiveness requires three distinct elements within the enhancer.
T12 1470-1529 Sentence denotes Two of these are potential binding sites for STAT proteins.
T12 1470-1529 Sentence denotes Two of these are potential binding sites for STAT proteins.