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PubMed:7730364 JSONTXT 31 Projects

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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Analysis of the role of protein kinase C-alpha, -epsilon, and -zeta in T cell activation.
T1 0-89 Sentence denotes Analysis of the role of protein kinase C-alpha, -epsilon, and -zeta in T cell activation.
T2 90-300 Sentence denotes T cells express multiple isotypes of protein kinase C (PKC) and although it is well accepted that PKCs have an important role in T cell activation, little is known about the function of individual PKC isotypes.
T2 90-300 Sentence denotes T cells express multiple isotypes of protein kinase C (PKC) and although it is well accepted that PKCs have an important role in T cell activation, little is known about the function of individual PKC isotypes.
T3 301-516 Sentence denotes To address this issue, mutationally active PKC-alpha, -epsilon, or -zeta have been transfected into T cells and the consequences for T cell activation determined. p21ras plays an essential role in T cell activation.
T3 301-516 Sentence denotes To address this issue, mutationally active PKC-alpha, -epsilon, or -zeta have been transfected into T cells and the consequences for T cell activation determined. p21ras plays an essential role in T cell activation.
T4 517-638 Sentence denotes Accordingly, the effects of the constitutively active PKCs were compared to the effects of mutationally activated p21ras.
T4 517-638 Sentence denotes Accordingly, the effects of the constitutively active PKCs were compared to the effects of mutationally activated p21ras.
T5 639-817 Sentence denotes The data indicate that PKC-epsilon and, to a lesser extent PKC-alpha but not -zeta, can regulate the transcription factors AP-1 and nuclear factor of activated T cells (NF-AT-1).
T5 639-817 Sentence denotes The data indicate that PKC-epsilon and, to a lesser extent PKC-alpha but not -zeta, can regulate the transcription factors AP-1 and nuclear factor of activated T cells (NF-AT-1).
T6 818-966 Sentence denotes The ability of PKC-epsilon to induce transactivation of NF-AT-1 and AP-1 was similar to the stimulatory effect of a constitutively activated p21ras.
T6 818-966 Sentence denotes The ability of PKC-epsilon to induce transactivation of NF-AT-1 and AP-1 was similar to the stimulatory effect of a constitutively activated p21ras.
T7 967-1054 Sentence denotes PKC-epsilon, but not PKC-alpha nor activated p21ras, was able to induce NF-KB activity.
T7 967-1054 Sentence denotes PKC-epsilon, but not PKC-alpha nor activated p21ras, was able to induce NF-KB activity.
T8 1055-1176 Sentence denotes Phorbol esters induce expression of CD69 whereas none of the activated PKC isotypes tested were able to have this effect.
T8 1055-1176 Sentence denotes Phorbol esters induce expression of CD69 whereas none of the activated PKC isotypes tested were able to have this effect.
T9 1177-1238 Sentence denotes Activated Src and p21ras were able to induce CD69 expression.
T9 1177-1238 Sentence denotes Activated Src and p21ras were able to induce CD69 expression.
T10 1239-1320 Sentence denotes These results indicate selective functions for different PKC isotypes in T cells.
T10 1239-1320 Sentence denotes These results indicate selective functions for different PKC isotypes in T cells.
T11 1321-1511 Sentence denotes Moreover, the data comparing the effects of activated Ras and PKC mutants suggest that PKC-alpha, p21ras, and PKC-epsilon are not positioned linearly on a single signal transduction pathway.
T11 1321-1511 Sentence denotes Moreover, the data comparing the effects of activated Ras and PKC mutants suggest that PKC-alpha, p21ras, and PKC-epsilon are not positioned linearly on a single signal transduction pathway.